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International audience; The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the three-dimensional folding of a 1 Mbp region of human chromosome 11 containing the β-globin genes by integrating looping interactions of the CCCTC-binding insulator protein CTCF determined comprehensively by chromosome conformation capture (3C) into a polymer model of chromatin. We find that CTCF-mediated cell type-specific interactions in erythroid cells are organized to favor contacts known to occur in vivo between the ...
free text keywords: Gene Regulation, Chromatin and Epigenetics, [ SDV.BBM.BP ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, Quantitative Biology - Biomolecules, [ PHYS.PHYS.PHYS-BIO-PH ] Physics [physics]/Physics [physics]/Biological Physics [], Quantitative Biology - Genomics, Physics - Biological Physics, Condensed Matter - Soft Condensed Matter
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Article . 2016
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