Reliable protein folding on non-funneled energy landscapes: the free energy reaction path

Article, Other literature type, Preprint English OPEN
Lois, Gregg; Blawzdziewicz, Jerzy; O'Hern, Corey S.; (2008)
  • Publisher: The Biophysical Society
  • Journal: Biophysical Journal,volume 95,issue 6,pages2,692-2,701 (issn: 0006-3495)
  • Related identifiers: doi: 10.1529/biophysj.108.133132, pmc: PMC2527276
  • Subject: Quantitative Biology - Biomolecules | Biophysics | Biophysical Theory and Modeling

A theoretical framework is developed to study the dynamics of protein folding. The key insight is that the search for the native protein conformation is influenced by the rate r at which external parameters, such as temperature, chemical denaturant or pH, are adjusted t... View more
  • References (21)
    21 references, page 1 of 3

    [1] C. Levinthal (1968) J. Chim. Phys. 65, 44-45; C. Levinthal (1969) in Mossbauer Spectroscopy in Biological Systems, eds. P. Debrunner, J. C. M. Tsibris and E. Munck (University of Illinois Press, Urbana), 22-24.

    [2] R. Zwanzig, A. Szabo and B. Bagchi (1992) Proc. Natl. Acad. Sci. 89, 20-22.

    [3] K. A. Dill and H. S. Chan (1997) Nature Struct. Mol. Biol. 4, 10-19.

    [4] S. S. Plotkin and J. N. Onuchic (2002), Q. Rev. Biophys. 35, 111-167.

    [5] D. J. Wales (2003) Energy Landscapes (Cambridge University Press, Cambridge).

    [6] H. S. Chan and K. A. Dill (1998) Proteins 30, 2-33.

    [7] R. L. Baldwin (1995) J. Biomolec. NMR 5, 103-109.

    [8] J. D. Bryngelson and P. G. Wolynes (1987) Proc. Natl. Acad. Sci. 84, 7524-7528; P. E. Leopold, M. Montal and J. N. Onuchic (1992) Proc. Natl. Acad. Sci. 89, 8721-8725; J. N. Onuchic, Z. Luthey-Schulten and P. G. Wolynes (1997) Annu. Rev. Phys. Chem. 48, 545-600.

    [9] T. Kiefhaber (1995) Proc. Natl. Acad. Sci. 92, 9029-9033; Q.-X. Hua, S. N. Gozani, R. E. Chance, J. A. Hoffman, B. H. Frank and M. A. Weiss (1997) Nature Struct. Biol. 2, 129-138; T. Pan and T. R. Sosnick (1997) Nature. Struct. Biol. 4, 931-938; J.-Y. Chang, L. Li and P.-H. Lai (2001) J. Biol. Chem. 276, 4845-4852; H. Im, M.-S. Woo, K. Y. Hwang and M.-H. Yu (2002) J. Biol. Chem. 277, 46347-46354.

    [10] I. E. T. Iben et. al. (1989) Phys. Rev. Lett. 62, 1916- 1919; R. D. Young et. al. (1991) Chemical Physics 158, 315-327.

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