Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

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Shi, Xuemei ; Chacko, Shaji ; Li, Feng ; Li, Depei ; Burrin, Douglas ; Chan, Lawrence ; Guan, Xinfu (2017)
  • Publisher: Elsevier
  • Journal: Molecular Metabolism, volume 6, issue 11, pages 1,350-1,359 (issn: 2212-8778, eissn: 2212-8778)
  • Related identifiers: doi: 10.1016/j.molmet.2017.08.009, pmc: PMC5681239
  • Subject: NTS, the nucleus of the solitary tract | CC, central canal | ChAT, choline acetyltransferase | PVH, the paraventricular hypothalamic nuclei | Internal medicine | icv, intracerebroventricular | Glucagon-Cre mice | Insulin sensitivity | Original Article | HGP, hepatic glucose production | GLP-1/2, glucagon-like peptides | CNO, clozapine N-oxide | GLP-1R (or Glp1r), GLP-1 receptor | DREADD, Designer Receptors Exclusively Activated by Designer Drugs | aCSF, artificial cerebrospinal fluid | GIR, glucose infusion rate | PPG, preproglucagon | ipGTT, intraperitoneal glucose tolerance test | Gcg, glucagon | EGP, endogenous glucose production | GNG, gluconeogenesis | Gluconeogenesis | DVC, the brainstem dorsal vagal complex | AP, area postrema | Endogenous glucose production | Preproglucagon neurons | DMH, the dorsomedial hypothalamic nuclei | Glucagon-like peptides | DMV, dorsal motor vagal nucleus | RC31-1245 | ARC, the arcuate nucleus | GLP-2R (or Glp2r), GLP-2 receptor
    mesheuropmc: sense organs

Objective: Glucagon-like peptides are co-released from enteroendocrine L cells in the gut and preproglucagon (PPG) neurons in the brainstem. PPG-derived GLP-1/2 are probably key neuroendocrine signals for the control of energy balance and glucose homeostasis. The object... View more
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