publication . Article . Other literature type . 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Rita T. Lawlor; Niccola Funel; Ivana Holcatova; Nathaniel Rothman; Beatrice Mohelníková-Duchoňová; Hermann Brenner; Núria Malats; Sonja I. Berndt; Phyllis J. Goodman; Juozas Kupcinskas; ...

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Open Access English

Published: 08 Feb 2018 Journal: Nature communications, volume 9, issue 1 (issn: 2041-1723,

Summary
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70

Abstract

In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10−8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci:...

doi: 10.1038/s41467-018-02942-5 , 10.17863/cam.25896 , 10.1038/s41467- ,

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Subjects

free text keywords: Article, Humans, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Genetic Predisposition to Disease, Proteins, Repressor Proteins, Polymorphism, Single Nucleotide, Databases, Genetic, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 4, Genome-Wide Association Study, Tensins, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, Cancer epidemiology, Càncer, Càncer de pàncrees, Cancer, Pancreas cancer, Science, Q, BODY-MASS INDEX, ASSOCIATION ANALYSES, GENE-EXPRESSION, TRANSCRIPTION FACTORS, RISK, IMPUTATION, ADENOCARCINOMA, Chemistry(all), Biochemistry, Genetics and Molecular Biology(all), Physics and Astronomy(all), Cancer and Oncology, Cancer och onkologi, Pancreatic cancer, medicine.disease, medicine, Expression quantitative trait loci, Pancreatic disease, Disease, Oncology, medicine.medical_specialty, HNF1B, business.industry, business, Internal medicine, Locus (genetics), Allele

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NIH| A RANDOMIZED TRIAL OF ASPIRIN AND MORTALITY IN US MDS, NIH| CORE--COLORECTAL AND PANCREATIC CANCER PATIENT REGISTRY, NHMRC| Epidemiology of Chronic Disease, Health Interventions and DNA Studies, NIH| BIOCHEMICAL MARKERS IN THE NURSE HEALTH STUDY COHORT, NHMRC| Planning, timing and quit success: A randomised controlled trial

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