publication . Article . Other literature type . 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Rita T. Lawlor; Niccola Funel; Ivana Holcatova; Nathaniel Rothman; Beatrice Mohelníková-Duchoňová; Hermann Brenner; Núria Malats; Sonja I. Berndt; Phyllis J. Goodman; Juozas Kupcinskas; ...
Open Access English
  • Published: 08 Feb 2018 Journal: Nature communications, volume 9, issue 1 (issn: 2041-1723, Copyright policy)
Abstract
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10−8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci:...
Subjects
free text keywords: Article, Humans, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Genetic Predisposition to Disease, Proteins, Repressor Proteins, Polymorphism, Single Nucleotide, Databases, Genetic, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 4, Genome-Wide Association Study, Tensins, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, Cancer epidemiology, Càncer, Càncer de pàncrees, Cancer, Pancreas cancer, Science, Q, BODY-MASS INDEX, ASSOCIATION ANALYSES, GENE-EXPRESSION, TRANSCRIPTION FACTORS, RISK, IMPUTATION, ADENOCARCINOMA, Chemistry(all), Biochemistry, Genetics and Molecular Biology(all), Physics and Astronomy(all), Cancer and Oncology, Cancer och onkologi, Pancreatic cancer, medicine.disease, medicine, Expression quantitative trait loci, Pancreatic disease, Disease, Oncology, medicine.medical_specialty, HNF1B, business.industry, business, Internal medicine, Locus (genetics), Allele
Funded by
NIH| A RANDOMIZED TRIAL OF ASPIRIN AND MORTALITY IN US MDS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL034595-02
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| CORE--COLORECTAL AND PANCREATIC CANCER PATIENT REGISTRY
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P50CA062924-05
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NHMRC| Epidemiology of Chronic Disease, Health Interventions and DNA Studies
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 209057
  • Funding stream: Programs
,
NIH| BIOCHEMICAL MARKERS IN THE NURSE HEALTH STUDY COHORT
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA049449-02
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NHMRC| Planning, timing and quit success: A randomised controlled trial
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 1009767
  • Funding stream: Project Grants
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