Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.

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Yoko Tabe ; Kensuke Kojima ; Shinichi Yamamoto ; Kazumasa Sekihara ; Hiromichi Matsushita ; Richard Eric Davis ; Zhiqiang Wang ; Wencai Ma ; Jo Ishizawa ; Saiko Kazuno ; Michael Kauffman ; Sharon Shacham ; Tsutomu Fujimura ; Takashi Ueno ; Takashi Miida ; Michael Andreeff
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 10, issue 9 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0137210, pmc: PMC4560410
  • Subject: Q | R | Research Article | Science | Medicine
    mesheuropmc: hemic and lymphatic diseases

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors. Exportin 1 (XPO1) mediates the nucleocytoplasmic transport of numerous molecules including oncogenic growth-regulating... View more