publication . Article . Other literature type . 2013

Common DNA Markers Can Account for More Than Half of the Genetic Influence on Cognitive Abilities

Plomin, R.; Haworth, C. M.; Meaburn, E. L.; Price, T. S.; Wellcome Trust Case Control Consortium; Davis, O. S.;
Open Access English
  • Published: 01 Apr 2013 Journal: Psychological Science (issn: 0956-7976, Copyright policy)
  • Country: United Kingdom
Abstract
For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification of individual variants to estimate the total heritability captured by common DNA markers on genotyping arrays. In the same sample of 3,154 pairs of 12-year-old twins, we directly compared twin-study heritability estimates for cognitive abilities (language, verbal, nonverbal...
Subjects
free text keywords: BF, Research Reports, cognitive ability, behavioral genetics, cognitive development, genetics, Child, Cognition, Genetic Markers, Genome-Wide Association Study, Genotype, Humans, Intelligence, Phenotype, Polymorphism, Single Nucleotide, Twins, Dizygotic, Twins, Monozygotic, psyc
Funded by
EC| GHCA
Project
GHCA
Genetics of High Cognitive Abilities
  • Funder: European Commission (EC)
  • Project Code: 295366
  • Funding stream: FP7 | SP2 | ERC
,
WT| WTCCC2 core activities
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 085475
  • Funding stream: Genetics, Genomics and Population Research
,
RCUK| Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0901245
  • Funding stream: MRC
,
WT| Identifying patterns of genome-wide association in the development of cognitive, behavioural and psychiatric disorders.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 088984
  • Funding stream: Population and Public Health
,
RCUK| Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0500079
  • Funding stream: MRC
38 references, page 1 of 3

Chabris, C. F., Hebert, B. M., Benjamin, D. J., Beauchamp, J., Cesarini, D., van der Loos, M., . . . Laibson, D. (2012). Most reported genetic associations with general intelligence are probably false positives. Psychological Science, 23, 1314-1323.

Cirulli, E. T., & Goldstein, D. B. (2010). Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nature Reviews Genetics, 11, 415-425. [OpenAIRE]

Davies, G., Tenesa, A., Payton, A., Yang, J., Harris, S. E., Liewald, D., . . . Deary, I. J. (2011). Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Molecular Psychiatry, 16, 996-1005. [OpenAIRE]

Davis, O. S. P., Butcher, L. M., Docherty, S. J., Meaburn, E. M., Curtis, C. J. C., Simpson, A., . . . Plomin, R. (2010). A threestage genome-wide association study of general cognitive ability: Hunting the small effects. Behavior Genetics, 40, 759-767. [OpenAIRE]

Davis, O. S. P., Haworth, C. M. A., & Plomin, R. (2009a). Dramatic increase in heritability of cognitive development from early to middle childhood: An 8-year longitudinal study of 8,700 pairs of twins. Psychological Science, 20, 1301-1308.

Davis, O. S. P., Haworth, C. M. A., & Plomin, R. (2009b). Learning abilities and disabilities: Generalist genes in early adolescence. Cognitive Neuropsychiatry, 14, 312-331.

Deary, I. J. (2012). Intelligence. Annual Review of Psychology, 63, 453-482.

Deary, I. J., Johnson, W., & Houlihan, L. M. (2009). Genetic foundations of human intelligence. Human Genetics, 126, 215-232. [OpenAIRE]

Deary, I. J., Penke, L., & Johnson, W. (2010). The neuroscience of human intelligence differences. Nature Reviews Neuroscience, 11, 201-211. [OpenAIRE]

Deary, I. J., Yang, J., Davies, G., Harris, S. E., Tenesa, A., Liewald, D., . . . Visscher, P. M. (2012). Genetic contributions to stability and change in intelligence from childhood to old age. Nature, 482, 212-215.

Gibson, G. (2012). Rare and common variants: Twenty arguments. Nature Reviews Genetics, 13, 135-145.

Haworth, C. M. A., Harlaar, N., Kovas, Y., Davis, O. S. P., Oliver, B. R., Hayiou-Thomas, M. E., . . . Plomin, R. (2007). Internet cognitive testing of large samples needed in genetic research. Twin Research and Human Genetics, 10, 554-563. [OpenAIRE]

Haworth, C. M. A., & Plomin, R. (2010). Quantitative genetics in the era of molecular genetics: Learning abilities and disabilities as an example. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 783-793. [OpenAIRE]

Haworth, C. M. A., Wright, M. J., Luciano, M., Martin, N. G., de Geus, E. J. C., van Beijsterveldt, C. E. M., . . . Plomin, R. (2010). The heritability of general cognitive ability increases linearly from childhood to young adulthood. Molecular Psychiatry, 15, 1112-1120.

Hindorff, L. A., MacArthur, J., Morales, J., Junkins, H. A., Hall, P. N., Klemm, A. K., & Manolio, T. A. (2013). A catalog of published genome-wide association studies. Retrieved from www.genome .gov/gwastudies

38 references, page 1 of 3
Abstract
For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification of individual variants to estimate the total heritability captured by common DNA markers on genotyping arrays. In the same sample of 3,154 pairs of 12-year-old twins, we directly compared twin-study heritability estimates for cognitive abilities (language, verbal, nonverbal...
Subjects
free text keywords: BF, Research Reports, cognitive ability, behavioral genetics, cognitive development, genetics, Child, Cognition, Genetic Markers, Genome-Wide Association Study, Genotype, Humans, Intelligence, Phenotype, Polymorphism, Single Nucleotide, Twins, Dizygotic, Twins, Monozygotic, psyc
Funded by
EC| GHCA
Project
GHCA
Genetics of High Cognitive Abilities
  • Funder: European Commission (EC)
  • Project Code: 295366
  • Funding stream: FP7 | SP2 | ERC
,
WT| WTCCC2 core activities
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 085475
  • Funding stream: Genetics, Genomics and Population Research
,
RCUK| Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0901245
  • Funding stream: MRC
,
WT| Identifying patterns of genome-wide association in the development of cognitive, behavioural and psychiatric disorders.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 088984
  • Funding stream: Population and Public Health
,
RCUK| Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0500079
  • Funding stream: MRC
38 references, page 1 of 3

Chabris, C. F., Hebert, B. M., Benjamin, D. J., Beauchamp, J., Cesarini, D., van der Loos, M., . . . Laibson, D. (2012). Most reported genetic associations with general intelligence are probably false positives. Psychological Science, 23, 1314-1323.

Cirulli, E. T., & Goldstein, D. B. (2010). Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nature Reviews Genetics, 11, 415-425. [OpenAIRE]

Davies, G., Tenesa, A., Payton, A., Yang, J., Harris, S. E., Liewald, D., . . . Deary, I. J. (2011). Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Molecular Psychiatry, 16, 996-1005. [OpenAIRE]

Davis, O. S. P., Butcher, L. M., Docherty, S. J., Meaburn, E. M., Curtis, C. J. C., Simpson, A., . . . Plomin, R. (2010). A threestage genome-wide association study of general cognitive ability: Hunting the small effects. Behavior Genetics, 40, 759-767. [OpenAIRE]

Davis, O. S. P., Haworth, C. M. A., & Plomin, R. (2009a). Dramatic increase in heritability of cognitive development from early to middle childhood: An 8-year longitudinal study of 8,700 pairs of twins. Psychological Science, 20, 1301-1308.

Davis, O. S. P., Haworth, C. M. A., & Plomin, R. (2009b). Learning abilities and disabilities: Generalist genes in early adolescence. Cognitive Neuropsychiatry, 14, 312-331.

Deary, I. J. (2012). Intelligence. Annual Review of Psychology, 63, 453-482.

Deary, I. J., Johnson, W., & Houlihan, L. M. (2009). Genetic foundations of human intelligence. Human Genetics, 126, 215-232. [OpenAIRE]

Deary, I. J., Penke, L., & Johnson, W. (2010). The neuroscience of human intelligence differences. Nature Reviews Neuroscience, 11, 201-211. [OpenAIRE]

Deary, I. J., Yang, J., Davies, G., Harris, S. E., Tenesa, A., Liewald, D., . . . Visscher, P. M. (2012). Genetic contributions to stability and change in intelligence from childhood to old age. Nature, 482, 212-215.

Gibson, G. (2012). Rare and common variants: Twenty arguments. Nature Reviews Genetics, 13, 135-145.

Haworth, C. M. A., Harlaar, N., Kovas, Y., Davis, O. S. P., Oliver, B. R., Hayiou-Thomas, M. E., . . . Plomin, R. (2007). Internet cognitive testing of large samples needed in genetic research. Twin Research and Human Genetics, 10, 554-563. [OpenAIRE]

Haworth, C. M. A., & Plomin, R. (2010). Quantitative genetics in the era of molecular genetics: Learning abilities and disabilities as an example. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 783-793. [OpenAIRE]

Haworth, C. M. A., Wright, M. J., Luciano, M., Martin, N. G., de Geus, E. J. C., van Beijsterveldt, C. E. M., . . . Plomin, R. (2010). The heritability of general cognitive ability increases linearly from childhood to young adulthood. Molecular Psychiatry, 15, 1112-1120.

Hindorff, L. A., MacArthur, J., Morales, J., Junkins, H. A., Hall, P. N., Klemm, A. K., & Manolio, T. A. (2013). A catalog of published genome-wide association studies. Retrieved from www.genome .gov/gwastudies

38 references, page 1 of 3
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