A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes

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Zugasti, Olivier; Thakur, Nishant; Belougne, Jerome; Squiban, Barbara; Kurz, C. Léopold; Soule, Julien; Omi, Shizue; Tichit, Laurent; Pujol, Nathalie; Ewbank, Jonathan J.;
  • Publisher: BioMed Central
  • Journal: BMC Biology,volume 14,issue 1 (issn: 1741-7007, eissn: 1741-7007)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1186/s12915-016-0256-3, pmc: PMC4850687
  • Subject: Agricultural and Biological Sciences(all) | Databases | Research Article | Epistasis | Signal transduction | [SDV.IMM]Life Sciences [q-bio]/Immunology | High-throughput screening | Functional genomics | Networks | Mitochondrial unfolded protein response | Osmotic stress | Biochemistry, Genetics and Molecular Biology(all) | Fungal pathogen | Bioinformatics | [ SDV.IMM ] Life Sciences [q-bio]/Immunology

Background Caenorhabditis elegans has emerged over the last decade as a useful model for the study of innate immunity. Its infection with the pathogenic fungus Drechmeria coniospora leads to the rapid up-regulation in the epidermis of genes encoding antimicrobial peptid... View more
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