Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers

Article English OPEN
Yoon S; Lee H; Kim TE; Lee S; Chee DH; Cho JY; Yu KS; Jang IJ;

Seonghae Yoon,1,* Howard Lee,2,* Tae-Eun Kim,1 SeungHwan Lee,1 Dong-Hyun Chee,3 Joo-Youn Cho,1 Kyung-Sang Yu,1 In-Jin Jang1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 2Clinical Trials Center, Seoul ... View more
  • References (15)
    15 references, page 1 of 2

    1. Iwanaga Y, Kimura T, Miyashita N, et al. Characterization of acetylcholinesterase-inhibition by itopride. Jpn J Pharmacol. 1994;66(3): 317-322. Available from: Accessed December 3, 2013.

    2. Kim YS, Kim TH, Choi CS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005;11(27):4210-4214.

    3. Katagiri F, Shiga T, Inoue S, Sato Y, Itoh H, Takeyama M. Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects. Pharmacology. 2006;77(3):115-121.

    4. Kreutzkamp B. [Functional dyspepsia. Itopride improves symptoms]. Med Monatsschr Pharm. 2006;29(10):387-388. German.

    5. Sun J, Yuan YZ, Holtmann G. Itopride in the treatment of functional dyspepsia in chinese patients: a prospective, multicentre, post-marketing observational study. Clin Drug Investig. 2011;31(12):865-875.

    6. Talley NJ, Tack J, Ptak T, Gupta R, Giguere M. Itopride in functional dyspepsia: results of two phase III multicentre, randomised, double-blind, placebo-controlled trials. Gut. 2008;57(6):740-746.

    7. Holtmann G, Talley NJ, Liebregts T, Adam B, Parow C. A placebocontrolled trial of itopride in functional dyspepsia. N Engl J Med. 2006;354(8):832-840.

    8. Nakajima M, Uematsu T, Nakajima S, Nagata O, Yamaguchi T. Phase 1 study of HSR-803. Jpn Pharmacol Ther. 1993;21(11):4157-4173.

    9. Mushiroda T, Douya R, Takahara E, Nagata O. The involvement of alfvin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug Metab Dispos. 2000;28(10): 1231-1237.

    10. Demol P, Ruoff HJ, Weihrauch TR. Rational pharmacotherapy of gastrointestinal motility disorders. Eur J Pediatr. 1989;148(6):489-495.

  • Related Organizations (3)
  • Metrics
Share - Bookmark