Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

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Darabi, Hatef; Beesley, Jonathan; Droit, Arnaud; Kar, Siddhartha; Nord, Silje; Moradi Marjaneh, Mahdi; Soucy, Penny; Michailidou, Kyriaki; Ghoussaini, Maya; Fues Wahl, Hanna; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Alonso, M. Rosario; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Beckmann, Matthias W.; Benitez, Javier; Bogdanova, Natalia V.; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Broeks, Annegien; Brüning, Thomas; Burwinkel, Barbara; Chang-Claude, Jenny; Choi, Ji-Yeob; Conroy, Don M.; Couch, Fergus J.; ... view all 114 authors
(2016)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports,volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep32512, pmc: PMC5013272
  • Subject: RC0254 | 3122 Cancers | Risk factors | EXPRESSION | ENHANCERS | SUSCEPTIBILITY LOCI | RISK LOCUS | CONSORTIUM | REVEALS | ASSOCIATION | Breast cancer | Article | General | Medizin | /dk/atira/pure/subjectarea/asjc/1000 | HUMAN GENOME | Genetics research | REGION | FUNCTIONAL VARIANTS
    • ddc: ddc:610

Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom ... View more