Nutraceuticals as potential therapeutic agents for colon cancer: a review

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Kuppusamy, Palaniselvam; Yusoff, Mashitah M.; Maniam, Gaanty Pragas; Ichwan, Solachuddin Jauhari Arief; Soundharrajan, Ilavenil; Govindan, Natanamurugaraj;
  • Publisher: Elsevier
  • Journal: Acta Pharmaceutica Sinica B,volume 4,issue 3,pages173-181 (issn: 2211-3835, eissn: 2211-3843)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.apsb.2014.04.002, pmc: PMC4629076
  • Subject: Therapeutics | HMG-CoA, 3-hydroxy-3-methyl-glutaryl CoA | MMP, matrix metallo-proteins | IGF, insulin-like growth factor | IL, interleukin | EPA, eicosapentaenoic acid | TCA, tricarboxylic acid cycle | ACC, acetyl CoA carboxylase | RM1-950 | Marine organisms | GADD, growth arrest and DNA damage | TRAIL, tumor necrosis factor-related apoptosis-induced ligand | HUVEC, human umbilical vein endothelial cell | Therapeutics. Pharmacology | Review | LDH, lactate dehydrogenase | ACL, ATP-citrate lyase | ASTX, astaxanthin | Colon cancer | ACF, aberrant crypt foci | NF-κB, nuclear factor-kappa B | Plant derivatives | 5-FU, 5-fluorouracil | DHA, decahexaenoic acid | DMH, 1,2-dimethylhydrazine | COX-2, cyclooxygenase 2 | DR, death receptor | VEGF, vascular endothelial growth factor | Nutraceuticals | PRAP, prolactin receptor associated protein | EGCG, epigallocatechingallate | FAS, fatty acid synthase | TNF, tumor necrosis factor

Colon cancer is a world-wide health problem and the second-most dangerous type of cancer, affecting both men and women. The modern diet and lifestyles, with high meat consumption and excessive alcohol use, along with limited physical activity has led to an increasing mo... View more
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