The Expression of Tubulin Cofactor A (TBCA) Is Regulated by a Noncoding Antisense Tbca RNA during Testis Maturation

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Nolasco, Sofia; Bellido, Javier; Gonçalves, João; Zabala, Juan Carlos; Soares, Helena; Tavares, Alexandra;
(2012)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 7,issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0042536, pmc: PMC3412815
  • Subject: Microtubule-associated proteins/chemistry | Animal Models | Molecular chaperones/metabolism | Research Article | Molecular cell biology | Molecular chaperones/genetics | RNA, Messenger/metabolism | RNA, Messenger/genetics | Molecular sequence data | Spermatogenesis/genetics | Mice | RNA, Untranslated/genetics | Models, molecular | Molecular chaperones/chemistry | Testis/growth & development | Mouse | Genetics | Amino acid sequence | Microtubule-associated proteins/genetics | Microtubule-associated proteins/metabolism | Animals | Transcription, Genetic | Base sequence | Cell line | Germ Cells | Cellular Types | Biology | RNA | RNA, Antisense/genetics | Medicine | Gene Function | Nucleic acids | RNA, Antisense/metabolism | Testis/metabolism | Spermatocytes/metabolism | Q | Gene knockdown techniques | R | Chromosomes, mammalian/genetics | RNA, Untranslated/metabolism | Model Organisms | Science | Genome/genetics | RNA interference | Male | Gene Expression | Gene expression regulation, developmental

BACKGROUND: Recently, long noncoding RNAs have emerged as pivotal molecules for the regulation of coding genes' expression. These molecules might result from antisense transcription of functional genes originating natural antisense transcripts (NATs) or from transcripti... View more
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