Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer’s Disease

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Segev, Yifat ; Livne, Adva ; Mints, Meshi ; Rosenblum, Kobi (2016)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Behavioral Neuroscience, volume 10 (issn: 1662-5153, eissn: 1662-5153)
  • Related identifiers: doi: 10.3389/fnbeh.2016.00170, pmc: PMC5011130
  • Subject: Alzheimer’s disease (AD) | ApoE4 | Neuroscience | high-fat diet | Original Research | metabolic stress | translation regulation | ATF4

Aging is the main risk factor for neurodegenerative diseases, including Alzheimer’s disease (AD). However, evidence indicates that the pathological process begins long before actual cognitive or pathological symptoms are apparent. The long asymptomatic phase and complex... View more
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