Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

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Rebecca Cook ; Georgia Zoumpoulidou ; Maciej T. Luczynski ; Simone Rieger ; Jayne Moquet ; Victoria J. Spanswick ; John A. Hartley ; Kai Rothkamm ; Paul H. Huang ; Sibylle Mittnacht (2015)
  • Publisher: Elsevier
  • Journal: Cell Reports, volume 10, issue 12, pages 2,006-2,018 (issn: 2211-1247, eissn: 2211-1247)
  • Related identifiers: pmc: PMC4386026, doi: 10.1016/j.celrep.2015.02.059
  • Subject: Article | Biology (General) | QH301-705.5
    mesheuropmc: eye diseases

Summary Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non-homologous e... View more
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