publication . Article . 2011

Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age

Watkins, Adam J.; Lucas, Emma S.; Wilkins, Adrian; Cagampang, Felino R.A.; Fleming, Tom P.;
Open Access English
  • Published: 01 Jan 2011 Journal: PLoS ONE, volume 6, issue 12 (issn: 1932-6203, eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Human and animal studies have revealed a strong association between periconceptional environmental factors, such as poor maternal diet, and an increased propensity for cardiovascular and metabolic disease in adult offspring. Previously, we reported cardiovascular and physiological effects of maternal low protein diet (LPD) fed during discrete periods of periconceptional development on 6-month-old mouse offspring. Here, we extend the analysis in 1 year aging offspring, evaluating mechanisms regulating growth and adiposity. Isocaloric LPD (9% casein) or normal protein diet (18% casein; NPD) was fed to female MF-1 mice either exclusively during oocyte maturation (f...
Subjects
mesheuropmc: hemic and lymphatic diseases
free text keywords: Metabolic Disorders, Cardiovascular System, Research Article, Biology, Developmental Biology, Medicine, Organogenesis, Cardiovascular, Organism Development, Anatomy and Physiology, Blood Chemistry, Q, Nutrition, R, Molecular Development, Biochemistry, Science, Metabolism, Aging, Embryology, Hypertension, Metabolic Pathways, Obesity
56 references, page 1 of 4

1. Taylor PD, Poston L (2007) Developmental programming of obesity in mammals. Exp Physiol 92: 287-298.

2. Robinson S (2007) Metabolic programming during pregnancy: epidemiological studies in humans. Genes Nutr 2: 31-32.

3. Garofano A, Czernichow P, Breant B (1997) In utero undernutrition impairs rat beta-cell development. Diabetologia 40: 1231-1234.

4. Bertin E, Gangnerau MN, Bellon G, Bailbe D, Arbelot De Vacqueur A, et al. (2002) Development of beta-cell mass in fetuses of rats deprived of protein and/ or energy in last trimester of pregnancy. Am J Physiol Regul Integr Comp Physiol 283: R623-630.

5. Garofano A, Czernichow P, Breant B (1999) Effect of ageing on beta-cell mass and function in rats malnourished during the perinatal period. Diabetologia 42: 711-718.

6. Vickers MH, Ikenasio BA, Breier BH (2001) IGF-I treatment reduces hyperphagia, obesity, and hypertension in metabolic disorders induced by fetal programming. Endocrinology 142: 3964-3973.

7. Augustyniak RA, Singh K, Zeldes D, Singh M, Rossi NF (2010) Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring. Am J Physiol Regul Integr Comp Physiol 298: R1375-1382. [OpenAIRE]

8. Guan H, Arany E, van Beek JP, Chamson-Reig A, Thyssen S, et al. (2005) Adipose tissue gene expression profiling reveals distinct molecular pathways that define visceral adiposity in offspring of maternal protein-restricted rats. Am J Physiol Endocrinol Metab 288: E663-673.

9. Fagundes AT, Moura EG, Passos MC, Santos-Silva AP, de Oliveira E, et al. (2009) Temporal evaluation of body composition, glucose homeostasis and lipid profile of male rats programmed by maternal protein restriction during lactation. Horm Metab Res 41: 866-873.

10. Bellinger L, Lilley C, Langley-Evans SC (2004) Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult rat. Br J Nutr 92: 513-520.

11. Fernandez-Twinn DS, Wayman A, Ekizoglou S, Martin MS, Hales CN, et al. (2005) Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring. Am J Physiol Regul Integr Comp Physiol 288: R368-373.

12. Berney DM, Desai M, Palmer DJ, Greenwald S, Brown A, et al. (1997) The effects of maternal protein deprivation on the fetal rat pancreas: major structural changes and their recuperation. J Pathol 183: 109-115.

13. Torrens C, Hanson MA, Gluckman PD, Vickers MH (2009) Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet. Br J Nutr 101: 27-33.

14. Brawley L, Itoh S, Torrens C, Barker A, Bertram C, et al. (2003) Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring. Pediatr Res 54: 83-90.

15. Watkins AJ, Lucas ES, Fleming TP (2010) Impact of the periconceptional environment on the programming of adult disease. Journal of Developmental Origins of Health and Disease 1: 87-95.

56 references, page 1 of 4
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Abstract
Human and animal studies have revealed a strong association between periconceptional environmental factors, such as poor maternal diet, and an increased propensity for cardiovascular and metabolic disease in adult offspring. Previously, we reported cardiovascular and physiological effects of maternal low protein diet (LPD) fed during discrete periods of periconceptional development on 6-month-old mouse offspring. Here, we extend the analysis in 1 year aging offspring, evaluating mechanisms regulating growth and adiposity. Isocaloric LPD (9% casein) or normal protein diet (18% casein; NPD) was fed to female MF-1 mice either exclusively during oocyte maturation (f...
Subjects
mesheuropmc: hemic and lymphatic diseases
free text keywords: Metabolic Disorders, Cardiovascular System, Research Article, Biology, Developmental Biology, Medicine, Organogenesis, Cardiovascular, Organism Development, Anatomy and Physiology, Blood Chemistry, Q, Nutrition, R, Molecular Development, Biochemistry, Science, Metabolism, Aging, Embryology, Hypertension, Metabolic Pathways, Obesity
56 references, page 1 of 4

1. Taylor PD, Poston L (2007) Developmental programming of obesity in mammals. Exp Physiol 92: 287-298.

2. Robinson S (2007) Metabolic programming during pregnancy: epidemiological studies in humans. Genes Nutr 2: 31-32.

3. Garofano A, Czernichow P, Breant B (1997) In utero undernutrition impairs rat beta-cell development. Diabetologia 40: 1231-1234.

4. Bertin E, Gangnerau MN, Bellon G, Bailbe D, Arbelot De Vacqueur A, et al. (2002) Development of beta-cell mass in fetuses of rats deprived of protein and/ or energy in last trimester of pregnancy. Am J Physiol Regul Integr Comp Physiol 283: R623-630.

5. Garofano A, Czernichow P, Breant B (1999) Effect of ageing on beta-cell mass and function in rats malnourished during the perinatal period. Diabetologia 42: 711-718.

6. Vickers MH, Ikenasio BA, Breier BH (2001) IGF-I treatment reduces hyperphagia, obesity, and hypertension in metabolic disorders induced by fetal programming. Endocrinology 142: 3964-3973.

7. Augustyniak RA, Singh K, Zeldes D, Singh M, Rossi NF (2010) Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring. Am J Physiol Regul Integr Comp Physiol 298: R1375-1382. [OpenAIRE]

8. Guan H, Arany E, van Beek JP, Chamson-Reig A, Thyssen S, et al. (2005) Adipose tissue gene expression profiling reveals distinct molecular pathways that define visceral adiposity in offspring of maternal protein-restricted rats. Am J Physiol Endocrinol Metab 288: E663-673.

9. Fagundes AT, Moura EG, Passos MC, Santos-Silva AP, de Oliveira E, et al. (2009) Temporal evaluation of body composition, glucose homeostasis and lipid profile of male rats programmed by maternal protein restriction during lactation. Horm Metab Res 41: 866-873.

10. Bellinger L, Lilley C, Langley-Evans SC (2004) Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult rat. Br J Nutr 92: 513-520.

11. Fernandez-Twinn DS, Wayman A, Ekizoglou S, Martin MS, Hales CN, et al. (2005) Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring. Am J Physiol Regul Integr Comp Physiol 288: R368-373.

12. Berney DM, Desai M, Palmer DJ, Greenwald S, Brown A, et al. (1997) The effects of maternal protein deprivation on the fetal rat pancreas: major structural changes and their recuperation. J Pathol 183: 109-115.

13. Torrens C, Hanson MA, Gluckman PD, Vickers MH (2009) Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet. Br J Nutr 101: 27-33.

14. Brawley L, Itoh S, Torrens C, Barker A, Bertram C, et al. (2003) Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring. Pediatr Res 54: 83-90.

15. Watkins AJ, Lucas ES, Fleming TP (2010) Impact of the periconceptional environment on the programming of adult disease. Journal of Developmental Origins of Health and Disease 1: 87-95.

56 references, page 1 of 4
Related research
12 research outcomes, page 1 of 2
12 research outcomes, page 1 of 2
Similar Outcomes
14 research outcomes, page 1 of 2
14 research outcomes, page 1 of 2
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publication . Article . 2011

Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age

Watkins, Adam J.; Lucas, Emma S.; Wilkins, Adrian; Cagampang, Felino R.A.; Fleming, Tom P.;