Hydrolysis of Ibuprofen Nitrile and Ibuprofen Amide and Deracemisation of Ibuprofen Using Nocardia corallina B-276

Other literature type, Article English OPEN
Lievano, Ricardo; Pérez, Herminia Inés; Manjarrez, Norberto; Solís, Aida; Solís-Oba, Myrna;

A novel application of whole cells of Nocardia corallina B-276 for the deracemisation of ibuprofen is reported. This microorganism successfully hydrolysed ibuprofen nitrile to ibuprofen amide, and ibuprofen amide to ibuprofen, using a suspension of cells in a potassium ... View more
  • References (20)
    20 references, page 1 of 2

    Kumaresan, C. S+ Ibuprofen (Dexibuprofen): The superior non-steroidal anti-inflammatory agents for development of pharmaceuticals. Int. J. Curr. Pharm. Res. 2010, 2, 1-3.

    Liu, Y.; Wang, F.; Tan, T. Cyclic resolution of racemic ibuprofen via coupled efficient lipase and acid-base catalysis. Chirality 2009, 21, 349-353.

    Biotechnol. Adv. 2010, 28, 725-741.

    Wang, M.X. Enantioselective biotransformations of nitriles in organic synthesis. Top. Catal. 2005, 35, 117-130.

    Pérez, H.I.; Manjarrez, N.; Luna, H.; Solís, A.; Ramírez, C. Nitrile hydratase activity of Nocardia corallina B-276. J. Braz. Chem. Soc. 2005, 16, 1150-1153.

    Kakeya, H.; Sakai, N.; Sugai, T.; Ohta, H. Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids. Tetahedron Lett. 1991, 32, 1343-1346.

    J. Pharm. Sci. 1992, 81, 149-154.

    8. Snell, D.; Colby, J. Enantioselective hydrolysis of racemic ibuprofen amide to S-(+)-ibuprofen by Rhodococcus AJ270. Enzyme Microb. Technol. 1999, 24, 160-163.

    9. van Pelt, S.; Zhang, M.; Otten, LG.; Holt, J.; Sorokin, D.Y.; van Rantwijk, F.; Black, GW.; Perry, J.J.; Sheldon, R.A. Probing the enantioselectivity of a diverse group of purified cobalt-centred nitrile hydratases. Org. Biomol. Chem. 2011, 9, 3011-3019.

    10. Warhust, A.M.; Fewson, C.A. Biotransformations catalyzed by the genus Rhodococcus. Crit. Rev. Biotechnol. 1994, 14, 29-73.

  • Similar Research Results (2)
  • Related Organizations (1)
  • Metrics
Share - Bookmark