Early brain connectivity alterations and cognitive impairment in a rat model of Alzheimer’s disease

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Muñoz-Moreno, Emma; Tudela, Raúl; López-Gil, Xavier; Soria, Guadalupe;
  • Publisher: BMC
  • Journal: Alzheimer’s Research & Therapy, volume 10 (issn: 1758-9193, eissn: 1758-9193)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1186/s13195-018-0346-2, pmc: PMC5803915
  • Subject: Rates (Animals de laboratori) | Alzheimer's disease | Magnetic resonance imaging | Connectomics | Neurology. Diseases of the nervous system | Neurosciences. Biological psychiatry. Neuropsychiatry | RC321-571 | RC346-429 | Malaltia d'Alzheimer | Rats as laboratory animals | Research | Alzheimer’s disease | Imatges per ressonància magnètica | Resting state | Transgenic | Rats | Animal model | Early biomarker

Background Animal models of Alzheimer’s disease (AD) are essential to understanding the disease progression and to development of early biomarkers. Because AD has been described as a disconnection syndrome, magnetic resonance imaging (MRI)-based connectomics provides a ... View more
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