Specialised information processing deficits and distinct metabolomics profiles following TM-domain disruption of Nrg1

Article, Other literature type English OPEN
O'Tuathaigh, C.M.P.; Mathur, N.; O'Callaghan, M.J.; MacIntyre, L.; Harvey, R.; Lai, D.; Waddington, J.L.; Pickard, B.S.; Watson, D.G.; Moran, Paula M.; (2016)
  • Publisher: Oxford University Press
  • Journal: volume 43,issue 5,pages1,100-1,113issn: 0586-7614, eissn: 1745-1701
  • Related identifiers: doi: 10.1093/schbul/sbw189, pmc: PMC5581893
  • Subject: Regular Articles | lipids | cognition | neuregulin | prepulse inhibition | schizophrenia | choline | mutant phenotype | antipsychotics | Life Sciences | Mutant Phenotype, Cognition, Metabolome, Antipsychotics, Neuregulin, Pre-pulse inhibition, Choline, Lipids, Schizophrenia | metabolome
    mesheuropmc: mental disorders

While there is considerable genetic and pathologic evidence for an association between neuregulin 1 (NRG1) dysregulation and schizophrenia, the underlying molecular and cellular mechanisms remain unclear. Mutant mice containing disruption of the transmembrane (TM) domai... View more
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