Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation.

Doctoral thesis English OPEN
Gewert, Karin;
  • Publisher: Center for Molecular Biomedicine, Lund University
  • Subject: dexamethasone | toxicology | toxikologi | Infektionsmedicin | pharmacognosy | signal transduction | cytosolic phospholipase A2 | farmaci | Infectious Medicine | okadaic acid | TNF-alpha | IL-1beta | macrophages | farmakognosi | mitogen-activated protein kinases | pharmacy | Farmakologi | glucocorticoids | protein phosphatases | Pharmacological sciences | protein kinase C

The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as i... View more
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