Analysis of structural chromosomal rearrangements in hematological neoplasias; Study of structural chromosomal rearrangements of cells of chronic lymphocytic leukemia after DSP30/IL2 stimulated cultivation

Doctoral thesis Czech RESTRICTED
Hrubá, Martina;
(2014)
  • Subject: multiklonalita; stimulated cultivation; complex karyotype; stimulovaná kultivace; chronic lymphocytic leukemia; klonální vývoj; komplexní změny karyotypu; multiclonality; clonal evolution; chronická lymfatická leukemie; cytogenetic analysis; cytogenetická analýza

Cytogenetic analysis of cells of chronic lymphocytic leukemia (CLL) is difficult because of their low proliferative activity. To obtain sufficient number of mitoses for performing chromosomal analysis a suitable stimulation of cell division is needed. Using DSP30/IL2 st... View more
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