RNA Interference Screen to Identify Pathways That Enhance or Reduce Nonviral Gene Transfer During Lipofection

Article, Other literature type English OPEN
Barker, Gregory A; Diamond, Scott L;
  • Publisher: Elsevier BV
  • Journal: Molecular Therapy,volume 16,issue 9,pages1,602-1,608 (issn: 1525-0016)
  • Related identifiers: pmc: PMC2854655, doi: 10.1038/mt.2008.147
  • Subject: Molecular Biology | Genetics | Drug Discovery | Pharmacology | Molecular Medicine | Article

Some barriers to DNA lipofection are well characterized; however, there is as yet no method of finding unknown pathways that impact the process. A druggable genome small-interfering RNA (siRNA) screen against 5,520 genes was tested for its effect on lipofection of human... View more
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