publication . Article . Other literature type . Preprint . 2019

Shared heritability and functional enrichment across six solid cancers

Karoline B. Kuchenbaecker; Andy R Ness; Graham G. Giles; Graham G. Giles; Nadine Tung; Thilo Dörk; Paul A. James; Hoda Anton-Culver; Emily White; Emily White; ...
Open Access English
  • Published: 25 Jan 2019
Abstract
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × ...
Subjects
free text keywords: Biolääketieteet - Biomedicine, Syöpätaudit - Cancers, Breast Neoplasms/diagnosis, Case-Control Studies, Colorectal Neoplasms/diagnosis, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Head and Neck Neoplasms/diagnosis, Humans, Inheritance Patterns, Lung Neoplasms/diagnosis, Male, Mental Disorders/ethnology, Neoplasm Proteins/genetics, Ovarian Neoplasms/diagnosis, Phenotype, Polymorphism, Single Nucleotide, Prostatic Neoplasms/diagnosis, Smoking/ethnology, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016425, Published Erratum, Science, Q, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, ANALYSES IDENTIFY, BREAST-CANCER, CELL-TYPES, GENETIC ARCHITECTURE, GENOME-WIDE ASSOCIATION, LUNG-CANCER, MENDELIAN RANDOMIZATION, PARTITIONING HERITABILITY, RISK-FACTORS, SUSCEPTIBILITY LOCI, Breast Neoplasms, Colorectal Neoplasms, Ovarian Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Prostatic Neoplasms, Neoplasm Proteins, Smoking, Mental Disorders, MD Multidisciplinary, /dk/atira/pure/core/keywords/icep, ICEP, /dk/atira/pure/core/keywords/centre_for_surgical_research, Centre for Surgical Research, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D052061, Research Support, N.I.H., Extramural, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, Càncer, Etiologia, Etiology, Medical Genetics, Medicinsk genetik, Codi genètic, Càncer - Aspectes genètics, Càncer - Estudi de casos, :Neoplasms [DISEASES], :Other subheadings::Other subheadings::/genetics [Other subheadings], :Other subheadings::Other subheadings::Other subheadings::/ethnology [Other subheadings], :Genetic Phenomena::Inheritance Patterns [PHENOMENA AND PROCESSES], :Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Case-Control Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT], :Neoplasias [ENFERMEDADES], :Otros calificadores::Otros calificadores::/genética [Otros calificadores], :Otros calificadores::Otros calificadores::Otros calificadores::/etnología [Otros calificadores], :Fenómenos Genéticos::Patrón de Herencia [FENÓMENOS Y PROCESOS], :Técnicas de Investigación::Métodos Epidemiológicos::Características de Estudios Epidemiológicos::Estudios Epidemiológicos::Estudios de Casos y Controles [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], 3111 Biomedicine, 1184 Genetics, developmental biology, physiology, 3122 Cancers, solid cancers; heritability; enrichment, 610, Article, Medicine and Health Sciences, Biology and Life Sciences, solid cancers, head and neck, Settore MED/42 - IGIENE GENERALE E APPLICATA, Càncer -- Etiologia, Càncer -- Aspectes genètics, Cancer genetics, Epidemiology, Genomics, Brjóstakrabbamein, Krabbamein, Erfðafræði, Erfðarannsóknir, Faraldsfræði, Publisher Correction, Cancer, medicine.disease, medicine, Ovarian cancer, Lung cancer, Breast cancer, Genetic correlation, Internal medicine, medicine.medical_specialty, Prostate cancer, Oncology, Colorectal cancer, Biology, Cancer Etiology, business.industry, business, Heritability, Genetics
Funded by
NIH| AUSTRALASIAN C0L0RECTAL CANCER FAMILY STUDY
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3U01CA074778-04S1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| International Partnership for Interdisciplinary Research Training
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1D43TW009112-01A1
  • Funding stream: FOGARTY INTERNATIONAL CENTER
,
NHMRC| Australian Prostate Cancer Collaboration (APCC) Bio - Resource
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 614296
  • Funding stream: NHMRC Enabling Grants
,
NIH| USC COMPREHENSIVE CANCER CENTER (CORE) SUPPORT
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30CA014089-17S1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NHMRC| Markers of androgen action, genetic variation and prostate cancer risk
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 450104
  • Funding stream: NHMRC Project Grants
Communities
Agricultural and Food Sciences
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