Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway

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Li, Jianshuang; Lu, Di; Dou, Hong; Liu, Huadie; Weaver, Kevin; Wang, Wenjun; Li, Jiada; Yeh, Edward T.H.; Williams, Bart O.; Zheng, Ling; Yang, Tao;

The development, growth, and renewal of skeletal tissues rely on the function of osteochondroprogenitors (OCPs). Protein sumoylation/desumoylation has emerged as a pivotal mechanism for stem cell/progenitor homeostasis, and excessive sumoylation has been associated with... View more
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