publication . Article . Other literature type . 2014

Safety Evaluation of a Bioglass–Polylactic Acid Composite Scaffold Seeded with Progenitor Cells in a Rat Skull Critical-Size Bone Defect

Ingo Marzi; Karam Eldesoqi; Bothaina M. Abd El-Hady; Caroline Seebach; Dirk Henrich; Mahmoud S. Arbid; Abeer M. El-Kady;
Open Access
  • Published: 03 Feb 2014 Journal: PLoS ONE, volume 9, page e87642 (eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Treating large bone defects represents a major challenge in traumatic and orthopedic surgery. Bone tissue engineering provides a promising therapeutic option to improve the local bone healing response. In the present study tissue biocompatibility, systemic toxicity and tumorigenicity of a newly developed composite material consisting of polylactic acid (PLA) and 20% or 40% bioglass (BG20 and BG40), respectively, were analyzed. These materials were seeded with mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) and tested in a rat calvarial critical size defect model for 3 months and compared to a scaffold consisting only of PLA. Serum was analyze...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, R, Science, Q, Research Article, Biology, Developmental Biology, Stem Cells, Adult Stem Cells, Mesenchymal Stem Cells, Cell Differentiation, Molecular Cell Biology, Cellular Types, Engineering, Bioengineering, Biological Systems Engineering, Materials Science, Biomaterials, Clinical Research Design, Preclinical Models, Surgery, Reconstructive Surgery, Trauma Surgery, Toxicology, Stem cell, Inflammation, medicine.symptom, medicine, Chemistry, Biocompatibility, Pathology, medicine.medical_specialty, Mesenchymal stem cell, Systemic inflammation, Bone healing, Progenitor cell, Tumor progression
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67 references, page 1 of 5

1 Dawson JI, Oreffo RO (2008) Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering. Arch Biochem Biophys 473: 124–131 S0003-9861(08)00165-3 [pii];10.1016/j.abb.2008.03.024 [doi] 18396145 [OpenAIRE] [PubMed] [DOI]

2 Kneser U, Schaefer DJ, Polykandriotis E, Horch RE (2006) Tissue engineering of bone: the reconstructive surgeon's point of view. J Cell Mol Med 10: 7–19 010.001.02 [pii].16563218 [OpenAIRE] [PubMed]

3 Mobini S, Hoyer B, Solati-Hashjin M, Lode A, Nosoudi N, et al (2013) Fabrication and characterization of regenerated silk scaffolds reinforced with natural silk fibers for bone tissue engineering. J Biomed Mater Res A 101: 2392–2404 10.1002/jbm.a.34537 [doi] 23436754 [OpenAIRE] [PubMed] [DOI]

4 Goulet JA, Senunas LE, DeSilva GL, Greenfield ML (1997) Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res 76–81.9186204 [OpenAIRE] [PubMed]

5 Dimitriou R, Jones E, McGonagle D, Giannoudis PV (2011) Bone regeneration: current concepts and future directions. BMC Med 9: 66 1741-7015-9-66 [pii];10.1186/1741-7015-9-66 [doi] 21627784 [OpenAIRE] [PubMed] [DOI]

6 Navarro M, Michiardi A, Castano O, Planell JA (2008) Biomaterials in orthopaedics. J R Soc Interface 5: 1137–1158 R03NH31248053204 [pii];10.1098/rsif.2008.0151 [doi] 18667387 [OpenAIRE] [PubMed] [DOI]

7 Gleeson JP, O'Brien FJ (2011) Composite Scaffolds for orthopedic Regenerative Medicine, Advances in in Composite Materials for Medicine and Nanotechnology, Dr. Brahim Attaf (Ed) 33–58. [OpenAIRE]

8 Jell G, Notingher I, Tsigkou O, Notingher P, Polak JM, et al (2008) Bioactive glass-induced osteoblast differentiation: a noninvasive spectroscopic study. J Biomed Mater Res A 86: 31–40 10.1002/jbm.a.31542 [doi] 17941016 [OpenAIRE] [PubMed] [DOI]

9 Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27: 3413–3431 S0142-9612(06)00123-2 [pii];10.1016/j.biomaterials.2006.01.039 [doi] 16504284 [OpenAIRE] [PubMed] [DOI]

10 Jones JR, Lin S, Yue S, Lee PD, Hanna JV, et al (2010) Bioactive glass scaffolds for bone regeneration and their hierarchical characterisation. Proc Inst Mech Eng H 224: 1373–1387.21287826 [PubMed]

11 Jones JR (2013) Review of bioactive glass: from Hench to hybrids. Acta Biomater 9: 4457–4486 S1742-7061(12)00399-6 [pii];10.1016/j.actbio.2012.08.023 [doi] 22922331 [OpenAIRE] [PubMed] [DOI]

12 Lai W, Garino J, Ducheyne P (2002) Silicon excretion from bioactive glass implanted in rabbit bone. Biomaterials 23: 213–217 S0142961201000977 [pii].11762840 [PubMed]

13 Leong KW, Brott BC, Langer R (1985) Bioerodible polyanhydrides as drug-carrier matrices. I: Characterization, degradation, and release characteristics. J Biomed Mater Res 19: 941–955 10.1002/jbm.820190806 [doi] 3880353 [OpenAIRE] [PubMed] [DOI]

14 Leong KW, D'Amore P, Maletta M, L, Langer R (2013) Bioerodible poly-anhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. J Biomed Mater Res 20: 51–64.

15 Rasal RM, Janokar AV, Hirt DE (2010) Poly(lactic acide) modifications. Prog Polymer Sci 33: 338–356.

67 references, page 1 of 5
Abstract
Treating large bone defects represents a major challenge in traumatic and orthopedic surgery. Bone tissue engineering provides a promising therapeutic option to improve the local bone healing response. In the present study tissue biocompatibility, systemic toxicity and tumorigenicity of a newly developed composite material consisting of polylactic acid (PLA) and 20% or 40% bioglass (BG20 and BG40), respectively, were analyzed. These materials were seeded with mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) and tested in a rat calvarial critical size defect model for 3 months and compared to a scaffold consisting only of PLA. Serum was analyze...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, R, Science, Q, Research Article, Biology, Developmental Biology, Stem Cells, Adult Stem Cells, Mesenchymal Stem Cells, Cell Differentiation, Molecular Cell Biology, Cellular Types, Engineering, Bioengineering, Biological Systems Engineering, Materials Science, Biomaterials, Clinical Research Design, Preclinical Models, Surgery, Reconstructive Surgery, Trauma Surgery, Toxicology, Stem cell, Inflammation, medicine.symptom, medicine, Chemistry, Biocompatibility, Pathology, medicine.medical_specialty, Mesenchymal stem cell, Systemic inflammation, Bone healing, Progenitor cell, Tumor progression
Download fromView all 4 versions
PLoS ONE
Article . 2014
Provider: Crossref
PLoS ONE
Article
Provider: UnpayWall
PLoS ONE
Article . 2014
67 references, page 1 of 5

1 Dawson JI, Oreffo RO (2008) Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering. Arch Biochem Biophys 473: 124–131 S0003-9861(08)00165-3 [pii];10.1016/j.abb.2008.03.024 [doi] 18396145 [OpenAIRE] [PubMed] [DOI]

2 Kneser U, Schaefer DJ, Polykandriotis E, Horch RE (2006) Tissue engineering of bone: the reconstructive surgeon's point of view. J Cell Mol Med 10: 7–19 010.001.02 [pii].16563218 [OpenAIRE] [PubMed]

3 Mobini S, Hoyer B, Solati-Hashjin M, Lode A, Nosoudi N, et al (2013) Fabrication and characterization of regenerated silk scaffolds reinforced with natural silk fibers for bone tissue engineering. J Biomed Mater Res A 101: 2392–2404 10.1002/jbm.a.34537 [doi] 23436754 [OpenAIRE] [PubMed] [DOI]

4 Goulet JA, Senunas LE, DeSilva GL, Greenfield ML (1997) Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res 76–81.9186204 [OpenAIRE] [PubMed]

5 Dimitriou R, Jones E, McGonagle D, Giannoudis PV (2011) Bone regeneration: current concepts and future directions. BMC Med 9: 66 1741-7015-9-66 [pii];10.1186/1741-7015-9-66 [doi] 21627784 [OpenAIRE] [PubMed] [DOI]

6 Navarro M, Michiardi A, Castano O, Planell JA (2008) Biomaterials in orthopaedics. J R Soc Interface 5: 1137–1158 R03NH31248053204 [pii];10.1098/rsif.2008.0151 [doi] 18667387 [OpenAIRE] [PubMed] [DOI]

7 Gleeson JP, O'Brien FJ (2011) Composite Scaffolds for orthopedic Regenerative Medicine, Advances in in Composite Materials for Medicine and Nanotechnology, Dr. Brahim Attaf (Ed) 33–58. [OpenAIRE]

8 Jell G, Notingher I, Tsigkou O, Notingher P, Polak JM, et al (2008) Bioactive glass-induced osteoblast differentiation: a noninvasive spectroscopic study. J Biomed Mater Res A 86: 31–40 10.1002/jbm.a.31542 [doi] 17941016 [OpenAIRE] [PubMed] [DOI]

9 Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27: 3413–3431 S0142-9612(06)00123-2 [pii];10.1016/j.biomaterials.2006.01.039 [doi] 16504284 [OpenAIRE] [PubMed] [DOI]

10 Jones JR, Lin S, Yue S, Lee PD, Hanna JV, et al (2010) Bioactive glass scaffolds for bone regeneration and their hierarchical characterisation. Proc Inst Mech Eng H 224: 1373–1387.21287826 [PubMed]

11 Jones JR (2013) Review of bioactive glass: from Hench to hybrids. Acta Biomater 9: 4457–4486 S1742-7061(12)00399-6 [pii];10.1016/j.actbio.2012.08.023 [doi] 22922331 [OpenAIRE] [PubMed] [DOI]

12 Lai W, Garino J, Ducheyne P (2002) Silicon excretion from bioactive glass implanted in rabbit bone. Biomaterials 23: 213–217 S0142961201000977 [pii].11762840 [PubMed]

13 Leong KW, Brott BC, Langer R (1985) Bioerodible polyanhydrides as drug-carrier matrices. I: Characterization, degradation, and release characteristics. J Biomed Mater Res 19: 941–955 10.1002/jbm.820190806 [doi] 3880353 [OpenAIRE] [PubMed] [DOI]

14 Leong KW, D'Amore P, Maletta M, L, Langer R (2013) Bioerodible poly-anhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. J Biomed Mater Res 20: 51–64.

15 Rasal RM, Janokar AV, Hirt DE (2010) Poly(lactic acide) modifications. Prog Polymer Sci 33: 338–356.

67 references, page 1 of 5
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