publication . Article . 2014

Single-marker and multi-marker mixed models for polygenic score analysis in family-based data

Bohossian, Nora; Saad, Mohamad; Legarra, Andrés; Martinez, Maria;
Open Access English
  • Published: 01 Jun 2014 Journal: BMC Proceedings, volume 8, issue Suppl 1, pages S63-S63 (eissn: 1753-6561, Copyright policy)
  • Publisher: BioMed Central
Abstract
Genome-wide association studies have proven successful but they remain underpowered for detecting variants of weaker effect. Alternative methods propose to test for association by using an aggregate score that combines the effects of the most associated variants. The set of variants that are to be aggregated may come from either of two modeling approaches: single-marker or multi-marker. The goal of this paper is to evaluate this alternative strategy by using sets of single-nucleotide polymorphisms identified by the two modeling approaches in the simulated pedigree data set provided for the Genetic Analysis Workshop 18. We focused on quantitative traits associati...
Subjects
free text keywords: Proceedings, General Biochemistry, Genetics and Molecular Biology, General Medicine, Alternative strategy, Mixed model, Replicate, Genetic association, Quantitative trait locus, Bioinformatics, Medicine, business.industry, business
Funded by
EC| UEPHA-MS
Project
UEPHA-MS
United Europeans for the Development of Pharmacogenomics in Multiple Sclerosis
  • Funder: European Commission (EC)
  • Project Code: 212877
  • Funding stream: FP7 | SP3 | PEOPLE
,
NIH| Identifying T2D Variants by DNA Sequencing in Multiethnic Samples
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01DK085584-01
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Identification and Replication of Type 2 Diabetes Genes in Mexican Americans
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01DK085501-02
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| GENETICS OF GALLBLADDER DISEASE IN MEXICAN AMERICANS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK053889-04
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

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