publication . Article . 2003

Biodistribution study of phosphonolipids: A class of non-viral vectors efficient in mice lung-directed gene transfer

DelÉpine, P.; Guillaume, C.; Montier, T.; Clément, J.C.; Yaouanc, J.J.; des Abbayes, Hervé; Berthou, F.; Le Pape, A.; Férec, C.;
Open Access English
  • Published: 01 Jan 2003
  • Publisher: HAL CCSD
Abstract
cited By 24; International audience; Background: A multitude of cationic lipids have been synthesized since they were first proposed for use in gene therapy. Cationic lipids are able to efficiently transfect cells both in vitro and in vivo. Whereas most research groups have focused their investigations on the toxicity of these molecules, and on the location of expression of the DNA transferred by these vectors, little has been done to determine their biodistribution and elimination pathways. Our group has developed a family of cationic lipids termed phosphonolipids. Following a large in vitro screening experiment, we have selected several molecules for in vivo t...
Subjects
free text keywords: Luciferases, Phospholipids, image analysis, mouse, urinary excretion, Animals, Female, hydrophilicity, Biological Availability, Liposomes, DNA vector, Gene Therapy, intravenous drug administration, animal experiment, article, nonviral gene delivery system, Lung, gene vector, Gene Transfer Techniques, plasmid DNA, bioavailability, lipoplex, lipid degradation, animal, nonhuman, metabolism, isotope labeling, [ CHIM ] Chemical Sciences, Gene Expression, technetium 99m, unclassified drug, comparative study, phosphonolipids, plasmid, beta galactosidase, lipid, Mice, Intravenous, [CHIM]Chemical Sciences, phosphonolipid derivative, phosphorus 32, priority journal, Injections, Genetic Vectors, gene transfer, Gene Targeting, in vivo study, Plasmids, carbon 14, liposome, controlled study, luciferase, DNA binding, drug distribution, drug release, phospholipid, methodology
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publication . Article . 2003

Biodistribution study of phosphonolipids: A class of non-viral vectors efficient in mice lung-directed gene transfer

DelÉpine, P.; Guillaume, C.; Montier, T.; Clément, J.C.; Yaouanc, J.J.; des Abbayes, Hervé; Berthou, F.; Le Pape, A.; Férec, C.;