Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds
Wrighton, Paul J.
Kiessling, Laura L.
- Publisher: Elsevier BV
Cell Stem Cell
(issn: 1934-5909, vol:
Genetics | Cell Biology | Molecular Medicine | Article
3D organ buds that can recapitulate organ function have myriad applications for regenerative and personalized medicine. Here, Takebe et al. (2015) describe a generalized method for organ bud formation, demonstrating that mechanosensitive mesenchymal stem cells drive condensation of heterotypic cell mixtures to create buds from diverse organs.