Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds

Article, 0038 English OPEN
Wrighton, Paul J. ; Kiessling, Laura L. (2015)
  • Publisher: Elsevier BV
  • Journal: Cell Stem Cell (issn: 1934-5909, vol: 16, pp: 453-454)
  • Related identifiers: doi: 10.1016/j.stem.2015.04.018
  • Subject: Genetics | Cell Biology | Molecular Medicine | Article

3D organ buds that can recapitulate organ function have myriad applications for regenerative and personalized medicine. Here, Takebe et al. (2015) describe a generalized method for organ bud formation, demonstrating that mechanosensitive mesenchymal stem cells drive condensation of heterotypic cell mixtures to create buds from diverse organs.
Share - Bookmark