PPARγ population shift produces disease-related changes in molecular networks associated with metabolic syndrome

Article English OPEN
Jurkowski, W; Roomp, K; Crespo, I; Schneider, J G; del Sol, A;
  • Publisher: Nature Publishing Group
  • Journal: Cell Death & Disease,volume 2,issue 8,pagee192 (eissn: 2041-4889)
  • Related identifiers: pmc: PMC3181420, doi: 10.1038/cddis.2011.74
  • Subject: metabolic syndrome | : Biochemistry, biophysics & molecular biology [F05] [Life sciences] | : Endocrinologie, métabolisme & nutrition [D06] [Sciences de la santé humaine] | Original Article | : Biochimie, biophysique & biologie moléculaire [F05] [Sciences du vivant] | disease-related networks | : Cardiovascular & respiratory systems [D03] [Human health sciences] | protein population shift | PPARγ | bi-stable switches | : Endocrinology, metabolism & nutrition [D06] [Human health sciences] | : Systèmes cardiovasculaire & respiratoire [D03] [Sciences de la santé humaine]

Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipocyte differentiation and has an important role in metabolic syndrome. Phosphorylation of the receptor's ligand-binding domain at serine 273 has been shown to change the expression of a l... View more
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