Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution

Doctoral thesis English OPEN
Westerhout, J.;
(2014)
  • Publisher: Division of Pharmacology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University
  • Subject: Blood-brain barrier | Brain extracellular fluid | Systems-based pharmacokinetic modeling | Microdialysis | Cerebrospinal fluid | Pharmacokinetics

In the development of drugs for the treatment of central nervous system (CNS) disorders, the prediction of human CNS drug action is a big challenge. Direct measurement of brain extracellular fluid (brainECF) concentrations is highly restricted in human. Therefore, unbou... View more
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