Caractérisation des processus d'ubiquitination régulant le facteur de transcription NF-kappaB au cours de l’activation lymphocytaire Rôle de l’E3 ligase TRIM13 et de la déubiquitinase USP34

Doctoral thesis French OPEN
Hatchi, Emeline;
(2014)
  • Publisher: HAL CCSD
  • Subject: Lymphocyte activation | Activation lymphocytaire | Ubiquitination | NF-kappaB | [SDV.IMM]Life Sciences [q-bio]/Immunology | Ubiquitinylation | [ SDV.IMM ] Life Sciences [q-bio]/Immunology

The transcription factor NF-KappaB plays a critical role in the development, homeostasis, the survival of the immune system, but also in the propagation of certain lymphomas. The optimal activation of NF-KappaB in response to the engagement of many immunoreceptors rely ... View more
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