Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.

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Dunford, L. J. ; Sinclair, K. D. ; Kwong, W. Y. ; Sturrock, C. ; Clifford, B. L. ; Giles, T. C. ; Gardner, D. S. (2014)
  • Publisher: Federation of American Societies for Experimental Biology (FASEB)
  • Journal: volume 28, issue 11, pages 4,880-4,892 (issn: 0892-6638, eissn: 1530-6860)
  • Related identifiers: doi: 10.1096/fj.14-255364, pmc: PMC4216596
  • Subject: renal | low protein diet | renal development | polyamines | Research Communications | developmental programming
    mesheuropmc: embryonic structures

This paper identifies a common nutritional pathway relating maternal through to fetal protein-energy malnutrition (PEM) and compromised fetal kidney development. Thirty-one twin-bearing sheep were fed either a control (n=15) or low-protein diet (n=16, 17 vs. 8.7 g crude protein/MJ metabolizable energy) from d 0 to 65 gestation (term, ∼145 d). Effects on the maternal and fetal nutritional environment were characterized by sampling blood and amniotic fluid. Kidney development was characterized by histology, immunohistochemistry, vascular corrosion casts, and molecular biology. PEM had little measureable effect on maternal and fetal macronutrient balance (glucose, total protein, total amino acids, and lactate were unaffected) or on fetal growth. PEM decreased maternal and fetal urea concentration, which blunted fetal ornithine availability and affected fetal hepatic polyamine production. For the first time in a large animal model, we associated these nutritional effects with reduced micro- but not macrovascular development in the fetal kidney. Maternal PEM specifically impacts the fetal ornithine cycle, affecting cellular polyamine metabolism and microvascular development of the fetal kidney, effects that likely underpin programming of kidney development and function by a maternal low protein diet.—Dunford, L. J., Sinclair, K. D., Kwong, W. Y., Sturrock, C., Clifford, B. L., Giles, T. C., Gardner, D. S.. Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.
  • References (75)
    75 references, page 1 of 8

    1. World Health Organization (2011) Nutrition Landscape Information System, World Health Organization, Geneva, Switzerland

    2. Black, R. E., Victora, C. G., Walker, S. P., Bhutta, Z. A., Christian, P., de Onis, M., Ezzati, M., Grantham-McGregor, S., Katz, J., Martorell, R., and Uauy, R.; Maternal and Child Nutrition Study Group (2013) Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 382, 427-451

    3. Eaton, S. B., and Konner, M. (1985) Paleolithic nutrition: a consideration of its nature and current implications. N. Engl. J. Med. 312, 283-289

    4. Popkin, B. M. (2006) Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases. Am. J. Clin. Nutr. 84, 289 -298

    5. Popkin, B. M. (2001) The nutrition transition and obesity in the developing world. J. Nutr. 131, 871S-873S

    6. Wallace, L. R. (1948) The growth of lambs before and after birth in relation to the level of nutrition. J. Agric. Sci. 38, 243-302

    7. Blaxter, K. L. (1957) The effects of defective nutrition during pregnancy in farm livestock. Proc. Nutr. Soc. 16, 52-58

    8. McCance, R. A. (1962) Food, growth, and time. Lancet 2, 621-626

    9. Hammond, J. (1932) Growth and the Development of Mutton Qualities in the Sheep, Oliver and Boyd, Edinburgh

    10. Barker, D. J., Gluckman, P. D., Godfrey, K. M., Harding, J. E., Owens, J. A., and Robinson, J. S. (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341, 938 -941

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