LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise

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Mantini, Dante; Petrucci, Francesca; Pieragostino, Damiana; Del Boccio, Piero; Di Nicola, Marta; Di Ilio, Carmine; Federici, Giorgio; Sacchetta, Paolo; Comani, Silvia; Urbani, Andrea;
  • Publisher: BMC
  • Journal: volume 8,issue 1,pages101-101issn: 1471-2105, eissn: 1471-2105
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC1847688, doi: 10.1186/1471-2105-8-101
  • Subject: Molecular Biology | Computational Biology | R858-859.7 | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Computer applications to medicine. Medical informatics | Proteomics | Electricity | QH301-705.5 | Methodology Article | Proteins | Biochemistry | Computer Science Applications | Adult | Humans | Biology (General)

BACKGROUND: Mass spectrometry protein profiling is a promising tool for biomarker discovery in clinical proteomics. However, the development of a reliable approach for the separation of protein signals from noise is required. In this paper, LIMPIC, a computational metho... View more
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