publication . Other literature type . Article . 2017

REVIEW ON IMIDAZOPYRIDINE DERIVATIVES AS POTENT REVERSIBLE INHIBITORS OF THE GASTRIC H+, K+-ATPASE

Ravindra S. Sonawane1*, Avinash V. Patil2;
Open Access
  • Published: 31 Jul 2017
  • Publisher: Zenodo
Abstract
The gastric H+, K+-ATPase is the preferred target for acid suppression. PPIs are acid-activated prodrug that requires acid protection. Once acid-activated, PPIs bind to cysteine of the ATPase, resulting in covalent, long-lasting inhibition. The currently available PPIs require around 3–5 days to achieve maximum acid inhibition at existent therapeutic doses, primarily due to their chemical structures and irreversible inhibition of H+,K+-ATPase. Therefore, many novel strategies to address the unmet needs of PPI therapy have been investigated, and acid pump antagonists (APAs) could play a promising role, as they provide faster onset and longer duration of action th...
Subjects
free text keywords: Gastric Acid Secretion, Gastric Disorders, Proton Pump Inhibitors, Acid Pump Antagonist, Imidazopyridine, Biological Activity.
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Zenodo
Other literature type . 2017
Provider: Datacite
ZENODO
Article . 2017
Provider: ZENODO
Zenodo
Other literature type . 2017
Provider: Datacite
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