publication . Article . Other literature type . 2012

A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness.

Zhijun Yao; Bin Hu; Chuanjiang Liang; Lina Zhao; Mike Jackson; Alzheimer's Disease Neuroimaging Initiative;
Open Access English
  • Published: 01 Jan 2012 Journal: PLoS ONE (issn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
In recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease. An understanding of the pathology of aMCI may benefit the development of effective clinical treatments for dementia. In this work, we measured the cortical thickness of 109 aMCI subjects and 99 normal controls (NC) twice over two years. The longitudinal changes and the cross-sectional differences between the two types of participants were explored using the vertex thickness values. The thickness of the cortex in aMCI was found significantly reduced in both longitudinal and between-group comparisons, mainly in the te...
Subjects
Medical Subject Headings: behavioral disciplines and activitiesmental disorders
free text keywords: Medicine, R, Science, Q, Research Article, Biology, Developmental Biology, Organism Development, Aging, Metamorphosis, Pattern Formation, Neuroscience, Cognitive Neuroscience, Cognition, Neurophysiology, Central Nervous System, Learning and Memory, Neurobiology of Disease and Regeneration, Computer Science, Numerical Analysis, Software Engineering, Software Tools, Diagnostic Medicine, Pathology, General Pathology, Biomarkers, Geriatrics, Long-Term Care, Global Health, Neurology, Dementia, Alzheimer Disease, Cognitive Neurology, Neuroimaging
Related Organizations
Funded by
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| CORE-- CLINICAL
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30AG010129-11S1
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| "MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5K01AG030514-02
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
EC| OPTIMI
Project
OPTIMI
Online Predictive Tools for Intervention in Mental Illness (OPTIMI)
  • Funder: European Commission (EC)
  • Project Code: 248544
  • Funding stream: FP7 | SP1 | ICT
Communities
Neuroinformatics
Download fromView all 4 versions
PLoS ONE
Article . 2012
http://dx.doi.org/10.1371/jour...
Other literature type . 2012
Provider: Datacite
51 references, page 1 of 4

1 Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, et al (2002) Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment: Results From the Cardiovascular Health Study. Jama-J Am Med Assoc 288: 1475–1483.

2 Rockwood K, Cosway S, Carver D, Jarrett P, Stadnyk K, et al (1999) The risk of dementia and death after delirium. Age Ageing 28: 551–556.10604507 [PubMed]

3 Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, et al (2009) Cortical Thickness Analysis to Detect Progressive Mild Cognitive Impairment: A Reference to Alzheimer's Disease. Dement Geriatr Cogn 28: 404–412. [OpenAIRE]

4 Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, et al (1999) Mild cognitive impairment: clinical characterization and outcome. Arc h Neurol 56: 303–308.10190820 [PubMed]

5 Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J? Intern Med 256: 183–194.15324362 [PubMed]

6 Du A-T, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, et al (2007) Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Brain 130: 1159–1166.17353226 [OpenAIRE] [PubMed]

7 Good CD, Scahill RI, Fox NC, Ashburner J, Friston KJ, et al (2002) Automatic Differentiation of Anatomical Patterns in the Human Brain: Validation with Studies of Degenerative Dementias. Neuroimage 17: 29–46.12482066 [OpenAIRE] [PubMed]

8 Shi F, Liu B, Zhou Y, Yu CS, Jiang TZ (2009) Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies. Hippocampus 19: 1055–1064.19309039 [PubMed]

9 Ashburner J, Friston KJ (2000) Voxel-Based Morphometry—The Methods. Neuroimage 11: 805–821.10860804 [PubMed]

10 Trivedi MA, Wichmann AK, Torgerson BM, Ward MA, Schmitz TW, et al (2006) Structural MRI discriminates individuals w ith Mild Cognitive Impairment from age-matched controls: A combined neuropsychological and voxel based morphometry study. Alzheimers Dement 2: 296–302.19020671 [OpenAIRE] [PubMed]

11 Karas GB, Scheltens P, Rombouts SA, Visser PJ, van-Schijndel RA, et al (2004) Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. Neuroimage 23: 708–716.15488420 [OpenAIRE] [PubMed]

12 Whitwell JL, Shiung MM, Przybelski SA, Weigand SD, Knopman DS, et al (2008) MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment. Neurology 70: 512–520.17898323 [OpenAIRE] [PubMed]

13 Jack-Jr CR, Weigand SD, Shiung MM, Przybelski SA, O'Brien PC, et al (2008) Atrophy Rates Accelerate in Amnestic Mild Cognitive Impairment. Neurology 70: 1740–1752.18032747 [OpenAIRE] [PubMed]

14 He Y, Chen Z, Evans A (2008) Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's Disease. J? Neurosci 28: 4756–4766.18448652 [OpenAIRE] [PubMed]

15 Yao ZJ, Zhang YC, Lin L, Zhou Y, Xu CL, et al (2010) Abnormal Cortical Networks in Mild Cognitive Impairment and Alzheimer's Disease. PLoS Comput Biol 6: 1–11.

51 references, page 1 of 4
Abstract
In recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease. An understanding of the pathology of aMCI may benefit the development of effective clinical treatments for dementia. In this work, we measured the cortical thickness of 109 aMCI subjects and 99 normal controls (NC) twice over two years. The longitudinal changes and the cross-sectional differences between the two types of participants were explored using the vertex thickness values. The thickness of the cortex in aMCI was found significantly reduced in both longitudinal and between-group comparisons, mainly in the te...
Subjects
Medical Subject Headings: behavioral disciplines and activitiesmental disorders
free text keywords: Medicine, R, Science, Q, Research Article, Biology, Developmental Biology, Organism Development, Aging, Metamorphosis, Pattern Formation, Neuroscience, Cognitive Neuroscience, Cognition, Neurophysiology, Central Nervous System, Learning and Memory, Neurobiology of Disease and Regeneration, Computer Science, Numerical Analysis, Software Engineering, Software Tools, Diagnostic Medicine, Pathology, General Pathology, Biomarkers, Geriatrics, Long-Term Care, Global Health, Neurology, Dementia, Alzheimer Disease, Cognitive Neurology, Neuroimaging
Related Organizations
Funded by
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| CORE-- CLINICAL
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30AG010129-11S1
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| "MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5K01AG030514-02
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
EC| OPTIMI
Project
OPTIMI
Online Predictive Tools for Intervention in Mental Illness (OPTIMI)
  • Funder: European Commission (EC)
  • Project Code: 248544
  • Funding stream: FP7 | SP1 | ICT
Communities
Neuroinformatics
Download fromView all 4 versions
PLoS ONE
Article . 2012
http://dx.doi.org/10.1371/jour...
Other literature type . 2012
Provider: Datacite
51 references, page 1 of 4

1 Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, et al (2002) Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment: Results From the Cardiovascular Health Study. Jama-J Am Med Assoc 288: 1475–1483.

2 Rockwood K, Cosway S, Carver D, Jarrett P, Stadnyk K, et al (1999) The risk of dementia and death after delirium. Age Ageing 28: 551–556.10604507 [PubMed]

3 Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, et al (2009) Cortical Thickness Analysis to Detect Progressive Mild Cognitive Impairment: A Reference to Alzheimer's Disease. Dement Geriatr Cogn 28: 404–412. [OpenAIRE]

4 Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, et al (1999) Mild cognitive impairment: clinical characterization and outcome. Arc h Neurol 56: 303–308.10190820 [PubMed]

5 Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J? Intern Med 256: 183–194.15324362 [PubMed]

6 Du A-T, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, et al (2007) Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Brain 130: 1159–1166.17353226 [OpenAIRE] [PubMed]

7 Good CD, Scahill RI, Fox NC, Ashburner J, Friston KJ, et al (2002) Automatic Differentiation of Anatomical Patterns in the Human Brain: Validation with Studies of Degenerative Dementias. Neuroimage 17: 29–46.12482066 [OpenAIRE] [PubMed]

8 Shi F, Liu B, Zhou Y, Yu CS, Jiang TZ (2009) Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies. Hippocampus 19: 1055–1064.19309039 [PubMed]

9 Ashburner J, Friston KJ (2000) Voxel-Based Morphometry—The Methods. Neuroimage 11: 805–821.10860804 [PubMed]

10 Trivedi MA, Wichmann AK, Torgerson BM, Ward MA, Schmitz TW, et al (2006) Structural MRI discriminates individuals w ith Mild Cognitive Impairment from age-matched controls: A combined neuropsychological and voxel based morphometry study. Alzheimers Dement 2: 296–302.19020671 [OpenAIRE] [PubMed]

11 Karas GB, Scheltens P, Rombouts SA, Visser PJ, van-Schijndel RA, et al (2004) Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. Neuroimage 23: 708–716.15488420 [OpenAIRE] [PubMed]

12 Whitwell JL, Shiung MM, Przybelski SA, Weigand SD, Knopman DS, et al (2008) MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment. Neurology 70: 512–520.17898323 [OpenAIRE] [PubMed]

13 Jack-Jr CR, Weigand SD, Shiung MM, Przybelski SA, O'Brien PC, et al (2008) Atrophy Rates Accelerate in Amnestic Mild Cognitive Impairment. Neurology 70: 1740–1752.18032747 [OpenAIRE] [PubMed]

14 He Y, Chen Z, Evans A (2008) Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's Disease. J? Neurosci 28: 4756–4766.18448652 [OpenAIRE] [PubMed]

15 Yao ZJ, Zhang YC, Lin L, Zhou Y, Xu CL, et al (2010) Abnormal Cortical Networks in Mild Cognitive Impairment and Alzheimer's Disease. PLoS Comput Biol 6: 1–11.

51 references, page 1 of 4
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