publication . Other literature type . Article . 2007

Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii

Peleg, A. Y.; Adams, J.; Paterson, D. L.;
Open Access English
  • Published: 09 Apr 2007
  • Publisher: American Society for Microbiology
<jats:title>ABSTRACT</jats:title> <jats:p>Tigecycline has an extended spectrum of in vitro antimicrobial activities, including that against multidrug-resistant <jats:italic>Acinetobacter</jats:italic>. After identifying bloodstream isolates of <jats:italic>Acinetobacter</jats:italic> with reduced susceptibilities to tigecycline, we performed a study to assess tigecycline efflux mediated by the resistance-nodulation-division-type transporter AdeABC. After exposure of two tigecycline-nonsusceptible isolates to the efflux pump inhibitor phenyl-arginine-β-naphthylamide (PABN), a fourfold reduction in the tigecycline MIC was observed. Both tigecycline-susceptible and...
free text keywords: Mechanisms of Resistance, Pharmacology (medical), Pharmacology, Infectious Diseases, Efflux, Acinetobacter baumannii, biology.organism_classification, biology, Antibiotics, medicine.drug_class, medicine, Neisseriaceae, Tigecycline, medicine.drug, Minocycline, Pseudomonas aeruginosa, medicine.disease_cause, Acinetobacter, Microbiology
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