Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REG as a therapeutic target

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Bett, J.S.; Goellner, G.M.; Woodman, B.; Pratt, G.; Rechsteiner, M.; Bates, G.P.;
(2006)

Huntington's disease (HD) is one of a group of neurodegenerative disorders caused by the pathological expansion of a glutamine tract. A hallmark of these so-called polyglutamine diseases is the presence of ubiquitylated inclusion bodies, which sequester various componen... View more
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