publication . Article . 2015

The interconnectedness of ageing:does the convoy principal apply?

Saffrey, Jill; Brown, James E.;
Open Access English
  • Published: 01 Apr 2015
  • Country: United Kingdom
Abstract
This is an excerpt from the content: The convoy principal states that any system is only as functional as its ‘slowest’ unit. As organisms are made up of interconnected networks of physiological systems, it is possible that this principle applies to the biology of ageing. Often biogerontology will focus either on organismal ageing (mechanisms associated with increased longevity of a lower model organism for example), ageing of an individual organ system (such as the cardiovascular/musculoskeletal/immune) or ageing at the cellular level (from telomere length to cellular senescence, with many different cell types being studied) without considering the interconnect...
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