publication . Article . 2015

The interconnectedness of ageing:does the convoy principal apply?

Saffrey, Jill; Brown, James E.;
Open Access English
  • Published: 01 Apr 2015
  • Country: United Kingdom
This is an excerpt from the content: The convoy principal states that any system is only as functional as its ‘slowest’ unit. As organisms are made up of interconnected networks of physiological systems, it is possible that this principle applies to the biology of ageing. Often biogerontology will focus either on organismal ageing (mechanisms associated with increased longevity of a lower model organism for example), ageing of an individual organ system (such as the cardiovascular/musculoskeletal/immune) or ageing at the cellular level (from telomere length to cellular senescence, with many different cell types being studied) without considering the interconnect...
Related Organizations

Cobley, J. N., P. R. Moult, et al. (2014). "Exercise improves mitochondrial and redox‐regulated stress  responses in the elderly: better late than never!" Biogerontology. 

Gossan,  N.,  R.  Boot‐Handford,  et  al.  (2014).  "Ageing  and  osteoarthritis:  a  circadian  rhythm  connection." Biogerontology.  [OpenAIRE]

Hazeldine, J. and J. M. Lord (2014). "Innate immunesenescence: underlying mechanisms and clinical  relevance." Biogerontology. 

Mabbott, N. A., A. Kobayashi, et al. (2014). "Aging and the mucosal immune system in the intestine."  Biogerontology. 

Mannick,  J.  B.,  G.  Del  Giudice,  et  al.  (2014).  "mTOR  inhibition  improves  immune  function  in  the  elderly." Sci Transl Med 6(268): 268ra179. 

Pararasa,  C.,  C.  J.  Bailey,  et  al.  (2014).  "Ageing,  adipose  tissue,  fatty  acids  and  inflammation."  Biogerontology.  [OpenAIRE]

Ranson,  R.  N.  and  M.  J.  Saffrey  (2015).  "Neurogenic  mechanisms  in  bladder  and  bowel  ageing."  Biogerontology.  [OpenAIRE]

Smith,  J.  A.,  T.  Leonardi,  et  al.  (2014).  "Extracellular  vesicles  and  their  synthetic  analogues  in  aging  and age‐associated brain diseases." Biogerontology. 

Smithey, M. J., J. L. Uhrlaub, et al. (2014). "Lost in translation: mice, men and cutaneous immunity in  old age." Biogerontology. 

Tullet,  J.  M.  (2014).  "DAF‐16  target  identification  in  C.  elegans:  past,  present  and  future."  Biogerontology. 

Any information missing or wrong?Report an Issue