publication . Article . 2010

Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring

Adam J. Watkins; Emma S. Lucas; Christopher Torrens; Jane K. Cleal; Lauren Green; Clive Osmond; Judith J. Eckert; William P. Gray; Mark A. Hanson; Tom P. Fleming;
Open Access English
  • Published: 04 Feb 2010
  • Publisher: Cambridge University Press
  • Country: United Kingdom
Abstract
<jats:p>Environmental perturbations during early mammalian development can affect aspects of offspring growth and cardiovascular health. We have demonstrated previously that maternal gestational dietary protein restriction in mice significantly elevated adult offspring systolic blood pressure. Therefore, the present study investigates the key mechanisms of blood pressure regulation in these mice. Following mating, female MF-1 mice were assigned to either a normal-protein diet (NPD; 18 % casein) or an isocaloric low-protein diet throughout gestation (LPD; 9 % casein), or fed the LPD exclusively during the pre-implantation period (3·5 d) before returning to the NP...
Subjects
free text keywords: Q1, Nutrition and Dietetics, Medicine (miscellaneous), Internal medicine, medicine.medical_specialty, medicine, Gestation, Pregnancy, medicine.disease, Biology, Angiotensin receptor, Offspring, Kidney, medicine.anatomical_structure, Endocrinology, Blood pressure, Low-protein diet, medicine.medical_treatment, Renin–angiotensin system
63 references, page 1 of 5

1. Barker DJ (2002) Fetal programming of coronary heart disease. Trends Endocrinol Metab 13, 364 - 368.

2. Hanson MA & Gluckman PD (2008) Developmental origins of health and disease: new insights. Basic Clin Pharmacol Toxicol 102, 90 - 93.

3. McMillen IC & Robinson JS (2005) Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85, 571 - 633.

4. Brawley L, Itoh S, Torrens C, et al. (2003) Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring. Pediatr Res 54, 83 - 90. [OpenAIRE]

5. Edwards LJ & McMillen IC (2002) Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep. Am J Physiol Regul Integr Comp Physiol 283, R669 - R679.

6. Langley SC & Jackson AA (1994) Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clin Sci (Lond) 86, 217 - 222.

7. Torrens C, Brawley L, Barker A, et al. (2003) Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring. J Physiol 547, 77 - 84.

8. Torrens C, Brawley L, Anthony F, et al. (2006) Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension 47, 982 - 987.

9. Cleal JK, Poore KR, Boullin JP, et al. (2007) Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proc Natl Acad Sci U S A 104, 9529 - 9533. [OpenAIRE]

10. Khan OA, Torrens C, Noakes DE, et al. (2005) Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function. Eur J Cardiothorac Surg 28, 811 - 815. [OpenAIRE]

11. Torrens C, Snelling TH, Chau R, et al. (2009) Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Exp Physiol 94, 1024 - 1033. [OpenAIRE]

12. Gopalakrishnan GS, Gardner DS, Rhind SM, et al. (2004) Programming of adult cardiovascular function after early maternal undernutrition in sheep. Am J Physiol Regul Integr Comp Physiol 287, R12 - R20.

13. Torrens C, Hanson MA, Gluckman PD, et al. (2009) Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet. Br J Nutr 101, 27 - 33.

14. Skeggs LT, Kahn JR & Shumway NP (1956) The preparation and function of the hypertensin-converting enzyme. J Exp Med 103, 295 - 299. [OpenAIRE]

15. Higuchi S, Ohtsu H, Suzuki H, et al. (2007) Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clin Sci (Lond) 112, 417 - 428.

63 references, page 1 of 5
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publication . Article . 2010

Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring

Adam J. Watkins; Emma S. Lucas; Christopher Torrens; Jane K. Cleal; Lauren Green; Clive Osmond; Judith J. Eckert; William P. Gray; Mark A. Hanson; Tom P. Fleming;