publication . Article . Other literature type . 2008

Pooled Analysis of the SAINT I and II Trials

Diener, Hans-Christoph; Lees, Kennedy R.; Lyden, Patrick; Grotta, Jim; Davalos, Antoni; Davis, Stephen M.; Shuaib, Ashfaq; Ashwood, Tim; Wasiewski, Warren; Alderfer, Vivian; ...
Open Access English
  • Published: 01 Jun 2008
  • Publisher: American Heart Association
  • Country: United Kingdom
Abstract
<p><b>Background and Purpose:</b> In animal models of acute ischemic stroke (AIS), the free radical-trapping agent NXY-059 showed promise as a neuroprotectant. SAINT I and II were randomized, placebo-controlled, double-blind trials to investigate the efficacy of NXY-059 in patients with AIS.</p>\ud \ud <p><b>Methods:</b> Patients with AIS received an infusion of intravenous NXY-059 or placebo within 6 hours from the onset of stroke symptoms. A pooled individual patient analysis was prespecified to assess the overall efficacy and to examine subgroups. The primary end point was the distribution of disability scores measured on the modified Rankin scale (mRS) at 90...
Subjects
free text keywords: Advanced and Specialised Nursing, Clinical Neurology, Cardiology and Cardiovascular Medicine, Cerebral infarction, medicine.disease, medicine, Physical therapy, medicine.medical_specialty, Placebo, Modified Rankin Scale, Stroke, business.industry, business, Clinical endpoint, Central nervous system disease, Activities of daily living, Thrombolysis, medicine.medical_treatment
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publication . Article . Other literature type . 2008

Pooled Analysis of the SAINT I and II Trials

Diener, Hans-Christoph; Lees, Kennedy R.; Lyden, Patrick; Grotta, Jim; Davalos, Antoni; Davis, Stephen M.; Shuaib, Ashfaq; Ashwood, Tim; Wasiewski, Warren; Alderfer, Vivian; ...