publication . Article . Other literature type . 2017

A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa

Jespers, Vicky; Kyongo, Jordan; Joseph, Sarah; Hardy, Liselotte; Cools, Piet; Crucitti, Tania; Mwaura, Mary; Ndayisaba, Gilles; Delany-Moretlwe, Sinead; Buyze, Jozefien; ...
Open Access
  • Published: 20 Sep 2017 Journal: Scientific Reports, volume 7 (eissn: 2045-2322, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Abstract In cross-sectional studies increased vaginal bacterial diversity has been associated with vaginal inflammation which can be detrimental for health. We describe longitudinal changes at 5 visits over 8 weeks in vaginal microbiota and immune mediators in African women. Women (N = 40) with a normal Nugent score at all visits had a stable lactobacilli dominated microbiota with prevailing Lactobacillus iners. Presence of prostate-specific antigen (proxy for recent sex) and being amenorrhoeic (due to progestin-injectable use), but not recent vaginal cleansing, were significantly associated with microbiota diversity and inflammation (controlled for menstrual cy...
Subjects
free text keywords: Medicine and Health Sciences, Biology and Life Sciences, FEMALE GENITAL-TRACT, CYTOKINE BIOMARKERS, INNATE IMMUNITY, HIV, EXPRESSION, CONTRACEPTION, ASSOCIATIONS, CHEMOKINES, MARKERS, Multidisciplinary, Biology, Proinflammatory cytokine, Prevotella bivia, ved/biology.organism_classification_rank.species, ved/biology, Nugent score, Dysbiosis, medicine.disease, medicine, Gardnerella vaginalis, medicine.disease_cause, Lactobacillus iners, biology.organism_classification, Immunology, Bacterial vaginosis, Atopobium vaginae, R, Science, Q, Article
Related Organizations
57 references, page 1 of 4

van de Wijgert, JHHM. The vaginal microbiota: what have we learned after a decade of molecular characterization?. PLoS One. 2014; 9: e105998 [OpenAIRE] [PubMed] [DOI]

Srinivasan, S. Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria. PLoS One. 2012; 7: e37818 [OpenAIRE] [PubMed] [DOI]

Verstraelen, H. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiol.. 2009; 9: 116 [OpenAIRE] [PubMed] [DOI]

Borgdorff, H. Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women. ISME J.. 2014; 8: 1781-93 [OpenAIRE] [PubMed] [DOI]

Li, J, McCormick, J, Bocking, A, Reid, G. Importance of vaginal microbes in reproductive health. Reprod. Sci.. 2012; 19: 235-42 [OpenAIRE] [PubMed] [DOI]

Taylor, BD, Darville, T, Haggerty, CL. Does bacterial vaginosis cause pelvic inflammatory disease?. Sex. Transm. Dis.. 2013; 40: 117-22 [OpenAIRE] [PubMed] [DOI]

Low, N. Intravaginal practices, bacterial vaginosis, and HIV infection in women: individual participant data meta-analysis. PLoS Med.. 2011; 8: e1000416 [OpenAIRE] [PubMed] [DOI]

Atashili, J. Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS. 2008; 22: 1493-1501 [OpenAIRE] [PubMed] [DOI]

Cohen, CR. Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples. PLoS Med.. 2012; 9: e1001251 [OpenAIRE] [PubMed] [DOI]

Frank, DN. Altered vaginal microbiota are associated with perinatal mother-to-child transmission of HIV in African women from Burkina Faso. J Acquir Immune Defic Syndr. 2012; 60: 299-306 [OpenAIRE] [PubMed] [DOI]

11.van de Wijgert, J. H. H. M. & Jespers, V. The global health impact of vaginal dysbiosis. Res. Microbiol. doi:10.1016/j.resmic.2017.02.003 (2017).

Anahtar, MN. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 2015; 42: 965-76 [OpenAIRE] [PubMed] [DOI]

Buve, A, Jespers, V, Crucitti, T, Fichorova, RN. The vaginal microbiota and susceptibility to HIV. AIDS. 2014; 28: 2333-44 [OpenAIRE] [PubMed] [DOI]

Nugent, RP, Krohn, MA, Hillier, SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J. Clin. Microbiol.. 1991; 29: 297-301 [OpenAIRE] [PubMed]

Gautam, R. Correlates of the molecular vaginal microbiota composition of African women. BMC Infect. Dis.. 2015; 15: 86 [OpenAIRE] [PubMed] [DOI]

57 references, page 1 of 4
Abstract
Abstract In cross-sectional studies increased vaginal bacterial diversity has been associated with vaginal inflammation which can be detrimental for health. We describe longitudinal changes at 5 visits over 8 weeks in vaginal microbiota and immune mediators in African women. Women (N = 40) with a normal Nugent score at all visits had a stable lactobacilli dominated microbiota with prevailing Lactobacillus iners. Presence of prostate-specific antigen (proxy for recent sex) and being amenorrhoeic (due to progestin-injectable use), but not recent vaginal cleansing, were significantly associated with microbiota diversity and inflammation (controlled for menstrual cy...
Subjects
free text keywords: Medicine and Health Sciences, Biology and Life Sciences, FEMALE GENITAL-TRACT, CYTOKINE BIOMARKERS, INNATE IMMUNITY, HIV, EXPRESSION, CONTRACEPTION, ASSOCIATIONS, CHEMOKINES, MARKERS, Multidisciplinary, Biology, Proinflammatory cytokine, Prevotella bivia, ved/biology.organism_classification_rank.species, ved/biology, Nugent score, Dysbiosis, medicine.disease, medicine, Gardnerella vaginalis, medicine.disease_cause, Lactobacillus iners, biology.organism_classification, Immunology, Bacterial vaginosis, Atopobium vaginae, R, Science, Q, Article
Related Organizations
57 references, page 1 of 4

van de Wijgert, JHHM. The vaginal microbiota: what have we learned after a decade of molecular characterization?. PLoS One. 2014; 9: e105998 [OpenAIRE] [PubMed] [DOI]

Srinivasan, S. Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria. PLoS One. 2012; 7: e37818 [OpenAIRE] [PubMed] [DOI]

Verstraelen, H. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiol.. 2009; 9: 116 [OpenAIRE] [PubMed] [DOI]

Borgdorff, H. Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women. ISME J.. 2014; 8: 1781-93 [OpenAIRE] [PubMed] [DOI]

Li, J, McCormick, J, Bocking, A, Reid, G. Importance of vaginal microbes in reproductive health. Reprod. Sci.. 2012; 19: 235-42 [OpenAIRE] [PubMed] [DOI]

Taylor, BD, Darville, T, Haggerty, CL. Does bacterial vaginosis cause pelvic inflammatory disease?. Sex. Transm. Dis.. 2013; 40: 117-22 [OpenAIRE] [PubMed] [DOI]

Low, N. Intravaginal practices, bacterial vaginosis, and HIV infection in women: individual participant data meta-analysis. PLoS Med.. 2011; 8: e1000416 [OpenAIRE] [PubMed] [DOI]

Atashili, J. Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS. 2008; 22: 1493-1501 [OpenAIRE] [PubMed] [DOI]

Cohen, CR. Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples. PLoS Med.. 2012; 9: e1001251 [OpenAIRE] [PubMed] [DOI]

Frank, DN. Altered vaginal microbiota are associated with perinatal mother-to-child transmission of HIV in African women from Burkina Faso. J Acquir Immune Defic Syndr. 2012; 60: 299-306 [OpenAIRE] [PubMed] [DOI]

11.van de Wijgert, J. H. H. M. & Jespers, V. The global health impact of vaginal dysbiosis. Res. Microbiol. doi:10.1016/j.resmic.2017.02.003 (2017).

Anahtar, MN. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 2015; 42: 965-76 [OpenAIRE] [PubMed] [DOI]

Buve, A, Jespers, V, Crucitti, T, Fichorova, RN. The vaginal microbiota and susceptibility to HIV. AIDS. 2014; 28: 2333-44 [OpenAIRE] [PubMed] [DOI]

Nugent, RP, Krohn, MA, Hillier, SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J. Clin. Microbiol.. 1991; 29: 297-301 [OpenAIRE] [PubMed]

Gautam, R. Correlates of the molecular vaginal microbiota composition of African women. BMC Infect. Dis.. 2015; 15: 86 [OpenAIRE] [PubMed] [DOI]

57 references, page 1 of 4
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue