Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 1... View more
1. Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206 (2015).
2. Shungin, D. et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518, 187-196 (2015).
3. Taylor, A. E. et al. Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet. 10, e1004799 (2014).
4. Pistelli, F., Aquilini, F. & Carrozzi, L. Weight gain after smoking cessation. Monaldi Arch. Chest Dis. 71, 81-87 (2009).
5. Morris, R. W. et al. Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open 5, e008808 (2015).
6. Kim, J. H. et al. Cigarette smoking increases abdominal and visceral obesity but not overall fatness: an observational study. PLoS ONE 7, e45815 (2012).
7. Owen-Smith, V. & Hannaford, P. C. Stopping smoking and body weight in women living in the United Kingdom. Br. J. Gen. Prac. 49, 989-990 (1999).
8. Lahmann, P. H., Lissner, L., Gullberg, B. & Berglund, G. Sociodemographic factors associated with long-term weight gain, current body fatness and central adiposity in Swedish women. Int. J. Obes. Relat. Metab. Disord. 24, 685-694 (2000).
9. Chiolero, A., Jacot-Sadowski, I., Faeh, D., Paccaud, F. & Cornuz, J. Association of cigarettes smoked daily with obesity in a general adult population. Obesity (Silver Spring) 15, 1311-1318 (2007).
10. Clair, C. et al. Dose-dependent positive association between cigarette smoking, abdominal obesity and body fat: cross-sectional data from a population-based survey. BMC Public Health 11, 23 (2011).