publication . 0044

The role of the innate immune system in the clearance of apoptotic cells

Thomas, Leanne;
Open Access English
Abstract
Rapid clearance of dying cells is a vital feature of apoptosis throughout development, tissue homeostasis and resolution of inflammation. The phagocytic removal of apoptotic cells is mediated by both professional and amateur phagocytes, armed with a series of pattern recognition receptors that participate in host defence and apoptotic cell clearance. CD14 is one such molecule. It is involved in apoptotic cell clearance (known to be immunosuppressive and anti-inflammatory) and binding of the pathogen-associated molecular pattern, lipopolysaccharides (a pro-inflammatory event). Thus CD14 is involved in the assembly of two distinct ligand-dependent macrophage respo...
49 references, page 1 of 4

ADACHI, H. & TSUJIMOTO, M. 2002. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. J Biol Chem, 277, 34264- 70.

AKAKURA, S., SINGH, S., SPATARO, M., AKAKURA, R., KIM, J.-I., ALBERT, M. L. & BIRGE, R. B. 2004. The opsonin MFG-E8 is a ligand for the [alpha]v[beta]5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. Experimental Cell Research, 292, 403-416.

AKIRA, S. & TAKEDA, K. 2004. Toll-like receptor signalling. Nat Rev Immunol, 4, 499- 511.

ANDERSON, H. A., MAYLOCK, C. A., WILLIAMS, J. A., PAWELETZ, C. P., SHU, H. & SHACTER, E. 2003. Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells. Nat Immunol, 4, 87-91.

ARUR, S., UCHE, U. E., REZAUL, K., FONG, M., SCRANTON, V., COWAN, A. E., MOHLER, W. & HAN, D. K. 2003. Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment. Developmental cell, 4, 587-598. [OpenAIRE]

AURELL, C. A. & WISTROM, A. O. 1998. Critical aggregation concentrations of gramnegative bacterial lipopolysaccharides (LPS). Biochem Biophys Res Commun, 253, 119-23.

BANERJEE, S., FRIGGERI, A., LIU, G. & ABRAHAM, E. 2010. The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis. Journal of Leukocyte Biology, 88, 973-979. [OpenAIRE]

BAZIL, V. & STROMINGER, J. L. 1991. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J Immunol, 147, 1567-74.

BIANCHI, M. E. 2009. HMGB1 loves company. Journal of Leukocyte Biology, 86, 573- 576.

BLEIJS, D. A., BINNERTS, M. E., VAN VLIET, S. J., FIGDOR, C. G. & VAN KOOYK, Y. 2000. Low-affinity LFA-1/ICAM-3 interactions augment LFA-1/ICAM-1- mediated T cell adhesion and signaling by redistribution of LFA-1. J Cell Sci, 113 ( Pt 3), 391-400.

BOMSZTYK, K., ROONEY, J. W., IWASAKI, T., RACHIE, N. A., DOWER, S. K. & SIBLEY, C. H. 1991. Evidence that interleukin-1 and phorbol esters activate NFkappa B by different pathways: role of protein kinase C. Cell Regul, 2, 329-35.

BOSMAN, G. J., WILLEKENS, F. L. & WERRE, J. M. 2005. Erythrocyte aging: a more than superficial resemblance to apoptosis? Cell Physiol Biochem, 16, 1-8. [OpenAIRE]

BOURNAZOU, I., POUND, J. D., DUFFIN, R., BOURNAZOS, S., MELVILLE, L. A., BROWN, S. B., ROSSI, A. G. & GREGORY, C. D. 2009. Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin. J Clin Invest, 119, 20- 32.

BRASS, D. M., HOLLINGSWORTH, J. W., MCELVANIA-TEKIPPE, E., GARANTZIOTIS, S., HOSSAIN, I. & SCHWARTZ, D. A. 2007. CD14 is an essential mediator of LPS-induced airway disease. American Journal of Physiology - Lung Cellular and Molecular Physiology, 293, L77-L83.

BRATTON, D. L. & HENSON, P. M. 2008. Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? Curr Biol, 18, R76-9. [OpenAIRE]

49 references, page 1 of 4
Abstract
Rapid clearance of dying cells is a vital feature of apoptosis throughout development, tissue homeostasis and resolution of inflammation. The phagocytic removal of apoptotic cells is mediated by both professional and amateur phagocytes, armed with a series of pattern recognition receptors that participate in host defence and apoptotic cell clearance. CD14 is one such molecule. It is involved in apoptotic cell clearance (known to be immunosuppressive and anti-inflammatory) and binding of the pathogen-associated molecular pattern, lipopolysaccharides (a pro-inflammatory event). Thus CD14 is involved in the assembly of two distinct ligand-dependent macrophage respo...
49 references, page 1 of 4

ADACHI, H. & TSUJIMOTO, M. 2002. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. J Biol Chem, 277, 34264- 70.

AKAKURA, S., SINGH, S., SPATARO, M., AKAKURA, R., KIM, J.-I., ALBERT, M. L. & BIRGE, R. B. 2004. The opsonin MFG-E8 is a ligand for the [alpha]v[beta]5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. Experimental Cell Research, 292, 403-416.

AKIRA, S. & TAKEDA, K. 2004. Toll-like receptor signalling. Nat Rev Immunol, 4, 499- 511.

ANDERSON, H. A., MAYLOCK, C. A., WILLIAMS, J. A., PAWELETZ, C. P., SHU, H. & SHACTER, E. 2003. Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells. Nat Immunol, 4, 87-91.

ARUR, S., UCHE, U. E., REZAUL, K., FONG, M., SCRANTON, V., COWAN, A. E., MOHLER, W. & HAN, D. K. 2003. Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment. Developmental cell, 4, 587-598. [OpenAIRE]

AURELL, C. A. & WISTROM, A. O. 1998. Critical aggregation concentrations of gramnegative bacterial lipopolysaccharides (LPS). Biochem Biophys Res Commun, 253, 119-23.

BANERJEE, S., FRIGGERI, A., LIU, G. & ABRAHAM, E. 2010. The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis. Journal of Leukocyte Biology, 88, 973-979. [OpenAIRE]

BAZIL, V. & STROMINGER, J. L. 1991. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J Immunol, 147, 1567-74.

BIANCHI, M. E. 2009. HMGB1 loves company. Journal of Leukocyte Biology, 86, 573- 576.

BLEIJS, D. A., BINNERTS, M. E., VAN VLIET, S. J., FIGDOR, C. G. & VAN KOOYK, Y. 2000. Low-affinity LFA-1/ICAM-3 interactions augment LFA-1/ICAM-1- mediated T cell adhesion and signaling by redistribution of LFA-1. J Cell Sci, 113 ( Pt 3), 391-400.

BOMSZTYK, K., ROONEY, J. W., IWASAKI, T., RACHIE, N. A., DOWER, S. K. & SIBLEY, C. H. 1991. Evidence that interleukin-1 and phorbol esters activate NFkappa B by different pathways: role of protein kinase C. Cell Regul, 2, 329-35.

BOSMAN, G. J., WILLEKENS, F. L. & WERRE, J. M. 2005. Erythrocyte aging: a more than superficial resemblance to apoptosis? Cell Physiol Biochem, 16, 1-8. [OpenAIRE]

BOURNAZOU, I., POUND, J. D., DUFFIN, R., BOURNAZOS, S., MELVILLE, L. A., BROWN, S. B., ROSSI, A. G. & GREGORY, C. D. 2009. Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin. J Clin Invest, 119, 20- 32.

BRASS, D. M., HOLLINGSWORTH, J. W., MCELVANIA-TEKIPPE, E., GARANTZIOTIS, S., HOSSAIN, I. & SCHWARTZ, D. A. 2007. CD14 is an essential mediator of LPS-induced airway disease. American Journal of Physiology - Lung Cellular and Molecular Physiology, 293, L77-L83.

BRATTON, D. L. & HENSON, P. M. 2008. Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? Curr Biol, 18, R76-9. [OpenAIRE]

49 references, page 1 of 4
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