publication . Article . 2016

ECM-DERIVED HYDROGELS FOR DENTAL STEM CELL DELIVERY

Viswanath, Aiswarya; Vanacker, Julie; Germain, Loic; Leprince, Julien G.; Diogenes, Anibal; Shakesheff, Kevin M.; White, Lisa J.; des Rieux, Anne;
Open Access English
  • Published: 05 Nov 2016
  • Publisher: Wiley
  • Country: China (People's Republic of)
Abstract
Decellularized mammalian extracellular matrices (ECM) have been widely accepted as an ideal substrate for repair and remodelling of numerous tissues in clinical and pre-clinical studies. Recent studies have demonstrated the ability of ECM scaffolds derived from site-specific homologous tissues to direct cell differentiation. The present study investigated the suitability of hydrogels derived from different source tissues: bone, spinal cord and dentine, as suitable carriers to deliver human apical papilla derived mesenchymal stem cells (SCAP) for spinal cord regeneration. Bone, spinal cord, and dentine ECM hydrogels exhibited distinct structural, mechanical, and ...
Subjects
free text keywords: ECM hydrogels, Dental stem cell delivery, Spinal cord, Bone, Dentine, Self-healing hydrogels, Mesenchymal stem cell, Cell biology, Spinal Cord Regeneration, Cellular differentiation, Stem cell, Organic chemistry, Extracellular matrix, Biomedical engineering, Spinal cord, medicine.anatomical_structure, medicine, Decellularization, Materials science

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publication . Article . 2016

ECM-DERIVED HYDROGELS FOR DENTAL STEM CELL DELIVERY

Viswanath, Aiswarya; Vanacker, Julie; Germain, Loic; Leprince, Julien G.; Diogenes, Anibal; Shakesheff, Kevin M.; White, Lisa J.; des Rieux, Anne;