publication . Other literature type . Article . 2004

Tissue transglutaminase in normal and abnormal wound healing: Review article

Timothy S. Johnson; Martin Griffin; Elisabetta A. M. Verderio;
Open Access
  • Published: 21 Jun 2004
  • Publisher: Springer Science and Business Media LLC
  • Country: United Kingdom
Abstract
A complex series of events involving inflammation, cell migration and proliferation, ECM stabilisation and remodelling, neovascularisation and apoptosis are crucial to the tissue response to injury. Wound healing involves the dynamic interactions of multiple cells types with components of the extracellular matrix (ECM) and growth factors. Impaired wound healing as a consequence of aging, injury or disease may lead to serious disabilities and poor quality of life. Abnormal wound healing may also lead to inflammatory and fibrotic conditions (such as renal and pulmonary fibrosis). Therefore identification of the molecular events underlying wound repair is essential...
Subjects
Medical Subject Headings: integumentary system
free text keywords: Organic Chemistry, Clinical Biochemistry, Biochemistry, Wound healing, Inflammation, medicine.symptom, medicine, Bioinformatics, Review article, Tissue transglutaminase, biology.protein, biology, Extracellular matrix, Pathology, medicine.medical_specialty, Pulmonary fibrosis, medicine.disease, Cell migration, business.industry, business, Wound care
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