Structure of the A-DNA Octamer d(GGCATGCC)

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Nunn, Christine M. ; Neidle, Stephen (1997)

The crystal structure of the self-complementary DNA octamer d(GGCATGCC) has been determined to a resolution of 2.38 ]k and R factor of 17.1%. The structure is an A-DNA octamer duplex with Watson-Crick base pairing along its length. This sequence extends the investigation of octamer duplexes of the type d(GGXaCC) which assume P61 packing within the crystallographic unit cell. The A-DNA duplex is non-linear with a helix axis curvature of 7 ° and bending towards the DNA minor groove. In view of the biological importance of protein recognition of some A-DNA sequences the minor-groove geometry and helix-axis curvature for this structure is compared with all others of the type d(GGXATXCC).
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