publication . Article . Other literature type . 2010

A homolog of the vertebrate pituitary adenylate cyclase-activating polypeptide is both necessary and instructive for the rapid formation of associative memory in an invertebrate

Zsolt Pirger; Zita László; Ildikó Kemenes; Gabor Toth; Dóra Reglődi; György Kemenes;
Open Access English
  • Published: 13 Oct 2010
  • Publisher: Society for Neuroscience
  • Country: United Kingdom
Similar to other invertebrate and vertebrate animals, cAMP dependent signaling cascades are key components of long-term memory (LTM) formation in the snail Lymnaea stagnalis, an established experimental model for studying evolutionarily conserved molecular mechanisms of long-term associative memory. Although a great deal is already known about the signaling cascades activated by cAMP, the molecules involved in the learning-induced activation of adenylate cyclase (AC) in Lymnaea remained unknown. Using Matrix-Assisted Laser Desorption/Ionization Time-of-flight (MALDI-TOF) mass spectroscopy in combination with biochemical and immunohistochemical methods, recently ...
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonists
free text keywords: Q, General Neuroscience, Articles, Lymnaea, biology.organism_classification, biology, Neuroscience, Classical conditioning, Nervous system, medicine.anatomical_structure, medicine, Lymnaea stagnalis, Adenylate kinase, Transcription (biology), Cyclase, Receptor antagonist, medicine.drug_class
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