publication . Article . Other literature type . 2015

Epstein–Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression

Sharada Ramasubramanyan; Kay Osborn; Rajaei Al-Mohammad; Ijiel B. Naranjo Perez-Fernandez; Jianmin Zuo; Nicolae Balan; Anja Godfrey; Harshil Patel; Gordon Peters; Martin Rowe; ...
Open Access English
  • Published: 20 Apr 2015
  • Publisher: Oxford University Press
  • Country: United Kingdom
Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic replication cycle. We asked whether a viral bZIP transcription factor, Zta (BZLF1, ZEBRA, EB1), drives some of these changes. Using genome-wide chromatin immunoprecipitation coupled to next-generation DNA sequencing (ChIP-seq) we established a map of Zta interactions across the human genome. Using sensitive transcriptome analyses we identified 2263 cellular genes whose expression is significantly changed during the EBV ...
free text keywords: QD0415, QH0471, QH301, QR355, Gene regulation, Chromatin and Epigenetics, Transcription factor, Gene, Gene expression, BZLF1, Genetics, Biology, Chromatin immunoprecipitation, Molecular biology, Lytic cycle, Trans-Activators, Chromatin
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