publication . Article . 2017

Severe Malignant Hypertension following Renal Artery Embolization: A Crucial Role for the Renal Microcirculation in the Pathogenesis of Hypertension?

Nahida Khan; John Jeans; Seyed Mahdi; Anna Maria Belli; Tarek F. Antonios;
Open Access English
  • Published: 18 Jul 2017
  • Country: United Kingdom
Malignant hypertension is the most severe form of hypertension that is usually fatal if not properly managed. It is usually associated with evidence of microvascular damage such as retinopathy and nephropathy. Renal artery embolization is a widely utilised tool for the management of a wide range of conditions including drug resistant renovascular hypertension in patients with end stage renal failure. In this report we describe two patients with mild-to-moderate hypertension who underwent renal artery embolization for reasons unrelated to their hypertension. Contrary to conventional wisdom, in both patients hypertension became more severe and difficult to control...
Persistent Identifiers
free text keywords: Coronary artery disease, medicine.disease, medicine, Renovascular hypertension, Embolism, Nephropathy, business.industry, business, Embolization, medicine.medical_treatment, Cardiology, medicine.medical_specialty, Internal medicine, Hemodialysis, Retinopathy, Angioplasty

1. Almgard LE, Ljungqvist A (1971) Experimental occlusion of the renal circulation in the dog. Scand J Urol Nephrol 5: 268-272.

2. Bergreen PW, Woodwide JR (1976) Treatment of uncontrolled hypertension by therapeutic renal infarction. Urology 8(6): 593-595.

3. Thompson JF, Fletcher EW, Wood RF, Chalmers DH, Taylor HM, et al. (1984) Control of hypertension after renal transplantation by embolisation of host kidneys. Lancet 2(8400): 424-427.

4. Russo D, Andreucci VE, Iaccarino V, Niola R, Dal Canton A, et al. (1988) Percutaneous renal embolisation in renovascular hypertension. Br Med J (Clin Res Ed) 296(6630): 1160-1161. [OpenAIRE]

5. Collins CS, Eggert CH, Stanson AJ, Garovic VD (2010) Long-term follow-up of renal function and blood pressure after selective renal arterial embolization. Perspect Vasc Surg Endovasc Ther 22(4): 254- 260.

6. Alavi JB, McLean GK (1983) Hypertension with renal carcinoma. An effect of arterial embolization. Cancer 52(1): 169-172.

7. Probert CS, Osborn DE, Watkin EM (1992) Malignant hypertension due to embolisation of a clear cell renal carcinoma. British Journal of Urology 70(1): 95-96.

8. Textor SC, Lerman L (2010) Renovascular hypertension and ischemic nephropathy. Am J Hypertens 23(11): 1159-1169. [OpenAIRE]

9. Millard FC, Hemingway AP, Cumberland DC, Brown CB (1989) Renal embolization for ablation of function in renal failure and hypertension. Postgrad Med J 65(768): 729-734. [OpenAIRE]

10. Hom D, Eiley D, Lumerman JH, Siegel DN, Goldfischer ER, et al. (1999) Complete renal embolization as an alternative to nephrectomy. J Urol 161(1): 24-27.

12. Mourad JJ, des Guetz G, Debbabi H, Levy BI (2008) Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation. Ann Oncol 19(5): 927-934.

11. Kappers MH, van Esch JH, Sleijfer S, Danser AH, van den Meiracker AH (2009) Cardiovascular and renal toxicity during angiogenesis inhibition: clinical and mechanistic aspects. J Hypertens 27(12): 2297-2309.

13. Steeghs N, Gelderblom H, Roodt JO, Christensen O, Rajagopalan P, et al. (2008) Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res 14(11): 3470-3476.

Any information missing or wrong?Report an Issue