publication . Article . Other literature type . 2016

Brain natriuretic peptide: Much more than a biomarker.

Luigino Calzetta; Paola Rogliani;
Open Access
  • Published: 15 Oct 2016 Journal: International Journal of Cardiology, volume 221, pages 1,031-1,038 (issn: 0167-5273, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Brain natriuretic peptide (BNP) modulates several biological processes by activating the natriuretic peptide receptor A (NPR-A). Atria and ventricles secrete BNP. BNP increases natriuresis, diuresis and vasodilatation, thus resulting in a decreased cardiac workload. BNP and NT-proBNP, which is the biologically inactive N-terminal portion of its pro-hormone, are fast and sensitive biomarkers for diagnosing heart failure. The plasma concentrations of both BNP and NT-proBNP also correlate with left ventricular function in patients with acute exacerbation of COPD, even without history of heart failure. Several studies have been conducted in vitro and in vivo, both i...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonistscardiovascular diseasescardiovascular system
free text keywords: BNP, NPR-A, asthma, COPD, human airway smooth muscle, Cardiology and Cardiovascular Medicine
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