publication . Book . 2014

Assessing methods for dealing with treatment crossover in clinical trials: A follow-up simulation study

Latimer, N.R.; Abrams, K.R.; Lambert, P.C.; Crowther, M.J.; Morden, J.P.;
Open Access English
  • Published: 05 Mar 2014
  • Publisher: Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield
  • Country: United Kingdom
Abstract
Background: Treatment switching commonly occurs in clinical trials of novel interventions, particularly in the advanced or metastatic cancer setting, which causes important problems for health technology assessment. Previous research has demonstrated which adjustment methods are suitable in specific scenarios, but scenarios considered have been limited. \ud Objectives: We aimed to assess statistical approaches for adjusting survival estimates in the presence of treatment switching in order to determine which methods are most appropriate in a new range of realistic scenarios, building upon previous research. In particular we consider smaller sample sizes, reduced...

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