miRNA-221 and miRNA-222 synergistically function to promote vascular calcification: MIR221/222 PROMOTE VASCULAR CALCIFICATION

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Mackenzie, N. C. W..; Staines, K. A..; Zhu, D..; Genever, P..; MacRae, V. E..;
  • Publisher: Wiley
  • Subject: Calcification | Enpp1 | microarray | miRNA | vascular smooth muscle cell | 571 Physiology & related subjects | QP Physiology | Biomedical Science Research Group | Wellbeing

Vascular calcification shares many similarities with skeletal mineralisation and involves the phenotypic trans-differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic cells within a calcified environment. Various microRNAs (miRs) are known to regulate ce... View more
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